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CNAA / Theses / 2012 / June /

Evolutionary-clinical aspects and optimization of the conduct of pregnancy and delivery in women with chronic Hepatitis B


Author: Castraveţ Irina
Degree:doctor of medicine
Speciality: 14.00.01 - Obstetrics and Gynecology
Year:2012
Scientific adviser: Olga Cerneţchi
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Victor Pântea
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 53-14.00.01
Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care

Status

The thesis was presented on the 26 June, 2012
Approved by NCAA on the 9 October, 2012

Abstract

Adobe PDF document0.89 Mb / in romanian

Keywords

hronic viral Hepatitis B, AgHBs, AgHBe, pregnancy, delivery, intrauterine growth restriction (IUGR

Summary

The work comprises 129 edited pages. It consists of introduction, 6 chapters, conclusions, practical recommendations, bibliography comprising 145 references, 4 annexes, 20 tables, 48 figures, and 1 algorithm. The obtained results were published in 9 scientific works.

Field of study: Obstetrics and Gynecology.

Purpose of study: to assess evolutionary-clinical peculiarities, to work out a diagnosis algorithm in pregnant women with AgHBs and to optimize the process of pregnancy and delivery. Research objectives: To study evolution of pregnancy and delivery, as well as perinatal results depending on either presence or absence of AgHBe. To establish peculiarities of feto-placental complex in pregnant women with chronic viral Hepatitis B. To work out the diagnosis algorithm of the type of hepatitis B in pregnant women with positive AgHBs. To study incidence of VHB transmission to the new-borns from mothers carriers of CVHB.

Methodology of scientific research: it is a clinical, analytical study. The examined lot comprised comparable groups and constituted the “witness-case” type.

Scientific novelty and originality: the study allowed for the first time in the RM to assess complexly the pregnancy evolution in pregnant women with chronic Hepatitis B.

The scientific problem approached in the research work has allowed working out the diagnosis algorithm of VHB in pregnancy. The performed study has highlighted a high degree of vertical transmission of VHB.

Theoretical significance the research: the results from the performed study have highlighted and completed knowledge about pregnancy evolution in pregnant women with chronic viral hepatitis B. The research work shows that the elaborated diagnosis algorithm of viral hepatitis B in pregnancy is efficient, practical and has a theoretical stratum for its demonstration.

Applicativ value of the research: the diagnostic algorithm of the VHB in pregnancy was developed in women with positive AgHBs in order to reduce perinatal morbidity.

Implementation of scientific results: the results of research have been implemented in the current therapeutic process of SPMI SCM no.1 in Chişinău. The study results are used in undergraduate and postgraduate training of the medical staff.

Summary


Evolutionary-clinical aspects and optimization of the conduct of pregnancy and delivery in women with chronic Hepatitis B” Research thesis for the degree of Doctor of Medicine, Chişinău, 2012 The work comprises 129 edited pages. It consists of introduction, 6 chapters, conclusions, practical recommendations, bibliography comprising 145 references, 4 annexes, 20 tables, 48 figures, and 1 algorithm. The obtained results were published in 9 scientific works. Key words: chronic viral Hepatitis B, AgHBs, AgHBe, pregnancy, delivery, intrauterine growth restriction (IUGR). Field of study: Obstetrics and Gynecology. Purpose of study: to assess evolutionary-clinical peculiarities, to work out a diagnosis algorithm in pregnant women with AgHBs and to optimize the process of pregnancy and delivery. Research objectives: To study evolution of pregnancy and delivery, as well as perinatal results depending on either presence or absence of AgHBe. To establish peculiarities of feto-placental complex in pregnant women with chronic viral Hepatitis B. To work out the diagnosis algorithm of the type of hepatitis B in pregnant women with positive AgHBs. To study incidence of VHB transmission to the new-borns from mothers carriers of CVHB. Methodology of scientific research: it is a clinical, analytical study. The examined lot comprised comparable groups and constituted the “witness-case” type. Scientific novelty and originality: the study allowed for the first time in the RM to assess complexly the pregnancy evolution in pregnant women with chronic Hepatitis B. The scientific problem approached in the research work has allowed working out the diagnosis algorithm of VHB in pregnancy. The performed study has highlighted a high degree of vertical transmission of VHB. Theoretical significance the research: the results from the performed study have highlighted and completed knowledge about pregnancy evolution in pregnant women with chronic viral hepatitis B. The research work shows that the elaborated diagnosis algorithm of viral hepatitis B in pregnancy is efficient, practical and has a theoretical stratum for its demonstration. Applicativ value of the research: the diagnostic algorithm of the VHB in pregnancy was developed in women with positive AgHBs in order to reduce perinatal morbidity. Implementation of scientific results: the results of research have been implemented in the current therapeutic process of SPMI SCM no.1 in Chişinău. The study results are used in undergraduate and postgraduate training of the medical staff.