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Synthesis, structure and properties of coordination compounds of cobalt and copper with 8-formylquinoline chalcogensemicarbazones


Author: Stratulat Elena
Degree:doctor of chemistry
Speciality: 02.00.01 - Inorganic chemistry
Year:2012
Scientific adviser: Mihail Revenco
doctor habilitat, professor, Moldova State University
Institution: Moldova State University
Scientific council: DH 30-02.00.01-25.12.03
Moldova State University

Status

The thesis was presented on the 10 February, 2012
Approved by NCAA on the 5 April, 2012

Abstract

Adobe PDF document – 2.66 Mb / in romanian

Keywords

coordination compounds, 8 – formylquinoline chalcogensemicarbazone, cobalt, copper, biological activity

Summary

The thesis consists of Introduction, 4 Chapters, Conclusions and Recommendations, Bibliography list with 158 references. It comprises 137 pages, 15 tables, 64 figures and 4 annexes. The obtained results were summarized in 19 scientific works.

Field of study and thesis objectives. This work is aimed to study ways of synthesis, stabilization and separation of cobalt and copper coordination compounds with 8- formylquinoline thiosemi- and semicarbazones, to establish the structure and antibacterial, antifungal and antitumor properties of the obtained compounds, to evaluate their analytical potential and to identify the application fields of their useful properties. The following objectives were set to meet the above-mentioned aims - to study the formation process of coordination compounds in solutions, to assess the analytical potential, to identify the conditions for separation of the forms, to elaborate reproductible methods for the synthesis of the complexes in solid state, to establish physical and chemical properties, structure of the separated compounds, to determine their antibacterial, antifungal and antitumor activities and the influence of the nature of the anion, ligand form, subtituent and chalcogen atom on these properties.

Scientific novelty and originality. There have been elaborated original methods of synthesis and separation of 16 complexes, 11 of which have been obtained for the first time. There was determined the coordination mode of the ligands, molecular and crystalline structure of the synthesized compounds. It was established the formation parameters and stability of copper(II) and cobalt of coordination compounds with 8-formylquinoline thiosemi- and semicarbazones in solutions. It was theoretically argumented the possibility of applying 4-phenyltiosemicarbazone derivative as spectrophotometric reagent for determination of cobalt and copper. It was also determined the impact of the anions, substituents in the thiosemicarbazidic fragment and nature of the chalcogen atoms on the physicochemical properties and biological activity of copper coordination compounds.

Theoretical significance and practical value. The formation of copper and cobalt coordination compounds with 8-formylquinoline chalcogensemicarbazones has been investigated and new information concerning the formation and stability of the complexes in solutions, has been used for the elaboration of new spectrophotometic method for determination of cobalt and copper. The structure of the solid coordination compounds was established and the impact of coordination on the biological and protolytical properties was determined. The nature of the complexe transformations in solutions was explained as well as the impact of a series of consecutive changes in the complexes on antibacterial and antineoplastic properties, has been explained in view to increas the bilogical activity.

Summary


Elena Stratulat, "Synthesis, structure and properties of coordination compounds of cobalt and copper with 8-formylquinoline chalcogensemicarbazones" PhD thesis in chemistry, Chisinau, 2012. The thesis consists of Introduction, 4 Chapters, Conclusions and Recommendations, Bibliography list with 158 references. It comprises 137 pages, 15 tables, 64 figures and 4 annexes. The obtained results were summarized in 19 scientific works. Key words: coordination compounds, 8 – formylquinoline chalcogensemicarbazone, cobalt, copper, biological activity. Field of study and thesis objectives. This work is aimed to study ways of synthesis, stabilization and separation of cobalt and copper coordination compounds with 8- formylquinoline thiosemi- and semicarbazones, to establish the structure and antibacterial, antifungal and antitumor properties of the obtained compounds, to evaluate their analytical potential and to identify the application fields of their useful properties. The following objectives were set to meet the above-mentioned aims - to study the formation process of coordination compounds in solutions, to assess the analytical potential, to identify the conditions for separation of the forms, to elaborate reproductible methods for the synthesis of the complexes in solid state, to establish physical and chemical properties, structure of the separated compounds, to determine their antibacterial, antifungal and antitumor activities and the influence of the nature of the anion, ligand form, subtituent and chalcogen atom on these properties. Scientific novelty and originality. There have been elaborated original methods of synthesis and separation of 16 complexes, 11 of which have been obtained for the first time. There was determined the coordination mode of the ligands, molecular and crystalline structure of the synthesized compounds. It was established the formation parameters and stability of copper(II) and cobalt of coordination compounds with 8-formylquinoline thiosemi- and semicarbazones in solutions. It was theoretically argumented the possibility of applying 4-phenyltiosemicarbazone derivative as spectrophotometric reagent for determination of cobalt and copper. It was also determined the impact of the anions, substituents in the thiosemicarbazidic fragment and nature of the chalcogen atoms on the physicochemical properties and biological activity of copper coordination compounds. Theoretical significance and practical value. The formation of copper and cobalt coordination compounds with 8-formylquinoline chalcogensemicarbazones has been investigated and new information concerning the formation and stability of the complexes in solutions, has been used for the elaboration of new spectrophotometic method for determination of cobalt and copper. The structure of the solid coordination compounds was established and the impact of coordination on the biological and protolytical properties was determined. The nature of the complexe transformations in solutions was explained as well as the impact of a series of consecutive changes in the complexes on antibacterial and antineoplastic properties, has been explained in view to increas the bilogical activity.