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CNAA / Theses / 2012 / May /

Arterial elasticity and central hemodynamics indices: evaluation and pathophysiological interdependence concepts

Author: Ciobanu Nicolae
Degree:doctor habilitat of medicine
Speciality: 14.00.06 - Cardiology and Rheumatology
Institution: Public Medico-Sanitary Institution Moldavian Institute of Cardiology
Scientific council: D 51-14.00.06
Public Medico-Sanitary Institution Moldavian Institute of Cardiology


The thesis was presented on the 11 May, 2012
Approved by NCAA on the 5 July, 2012


Adobe PDF document2.82 Mb / in romanian


artery elasticity, heart diastolic and systolic dysfunction, „handgrip” test, endothelium dependent vascular reactivity, microalbuminuria


The theses is related on 297 pages, and consists of introduction, 8 chapters, conclusions, practical recommendations, abstracts in Romanian, English, Russian and bibliography of 229 sources. Illustrative mater contains 40 tables and 298 figures. The results are published in 94 scientific works.

Domain of research: functional cardiology.

Aim of research: Evaluation of artery elasticity indices with central hemodynamics indices in patients with left ventricle diastolic and systolic dysfunction, as well as in vitro estimation of the peripheral vascular and coronary reactivity.

Objectives of research: Estimation of the pathophysiological interrelations concerning artery elasticity indices and left ventricle indices dependently of heart failure evolution pattern and therapy, the in vitro assessment of aorta and coronary system vasomotricity in experimental heart failure.

Solved scientific problem in this study: Have been underlined the opportunities of interdependence between big and small artery elasticity indices and heart geometric and functional changes characteristic to left ventricle diastolic or systolic dysfunction. Methodology of scientific study: echocardiography, artery elasticity indices assay thereby pulsatile wave analysis, „handgrip” test, rat isolated aorta rings and isolated heart perfusion.

Novelty and originality of research: Primary was evaluated the trait of big and small artery elasticity indices correlation with heart geometric and functional parameters in patients with diastolic or systolic dysfunction, as well as the influence of diverse therapeutic approaches.

Applied value:Is emphasized the role of the artery elasticity disorders in hemodynamics impairments development which may be improved by hypotensive and hypolipemiant treatment.

Practical implementation: The study results were proven as scientific point and have been implemented in the clinic of the Institute of Cardiology.