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Coordinative compounds of zinc and vanadium, their evaluation and influence on the stimulaton of bone regeneration in periodontal tissues after the use of titanium implants

Author: Granciuc Gheorge
Degree:doctor habilitat of medicine
Speciality: 14.00.21 - Stomatology
Scientific consultants: Pavel Godoroja (decedat)
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Aurelian Gulea
doctor habilitat, professor, Moldova State University
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.21
State University of Medicine and Pharmacy "Nicolae Testemitanu"


The thesis was presented on the 28 November, 2012
Approved by NCAA on the 20 December, 2012


Adobe PDF document0.85 Mb / in romanian


coordinative compounds, zinc, vanadium, paradontitis, periodontal tissues, bone regeneration processes, titanium implants, osteointegration, dentistry treatment


The thesis consists of introduction, five chapters, conclusions and recommendations, bibliography includes 301 titles, annexes 44 has total volume of 200 basic text pages, 64 tables, 21 figures. Obtained results were exposed to 70 publications.

The domain of study: Dentistry. Aim: evaluation of bone regeneration processes in tissues after the administration of coordinative compounds of zinc and vanadium, reasoning the efficiency of such compounds in paradontology and implantology; developing effective methods for clinical diagnosis, minimally invasive and prophylactic treatment to reduce paradontal complications; improving precocious and late prognostics and results of treatment after dental titanium implants insertion.

Scientific novelty: For the first time a systemic, multiplane and comparative study was performed, allowing detailed review over the pathogenesis of paradontopathologies. The metabolic changes in tissue and bone cells were elucidated for obtaining a more precise therapeutic guideline on drug utilization of new bone regeneration compounds which were obtained based on transition metals and their coordinative compounds.

The scientific problem solved in the thesis is determined by the elucidation of mechanisms about the action of coordinative compounds of Zinc and Vanadium on paradontal tissue in normality and pathology and also in the insertion of dental implants. The results enlarge the theoretical knowledge about their biological properties, also offering new possibilities to explore them as medical compounds.

Theoretical significance: Elucidating mechanisms and actions of coordinative zinc and vanadium compounds on the body in normal and pathology would extend theoretical knowledge about their biological properties, also offering new opportunities for explorations in the future, in order to obtain effective medical preparations.

Results: The algorithm of indications and contraindications for implants insertion for patients with paradontal disorders was elaborated. As a test for the diagnosis of periodontal tissue pathology and the effectiveness of treatment, the activity of enzymes with determinant role on protein, carbohydrates and mineral metabolism, could be used. A program for early diagnosis of metabolic disorders on patients with paradontal pathologies have been developed, using modern biochemical methods.

Implementation of scientific results: The results of study, complex methods of diagnosis and treatment were applied in the Clinic of Orthodontics of Children’s Hospital of Moldovan Health Ministry, Dental Clinic of Medical University “N. Testemitanu”, and in the didactic teaching of the Department of Surgery, Pedodontics and Orthodontics, State Medical University “N. Testemitanu; Municipal Dental Clinic for adults; Municipal Dental Clinic for children; Republican Dental Clinic; Dental Clinic “Fala Dental”; Dental Clinic “Ceradent”, Dental Clinic “Medicina pentru toti”; Biochemical laboratory of State Medical University “N. Testemitanu”.