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Specifics of cognitive-affective disorders at children with cerebellar tumors


Author: Litovcenco Anatolii
Degree:doctor habilitat of biology
Speciality: 03.00.13 - Human and animal physiology
Year:2012
Scientific consultants: Victor Lacusta
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Eva Gudumac
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: Institute of Physiology and Sanacreatology of the ASM
Scientific council: DH 07-03.00.13
Institute of Physiology and Sanacreatology of the ASM

Status

The thesis was presented on the 30 November, 2012
Approved by NCAA on the 20 December, 2012

Abstract

Adobe PDF document0.88 Mb / in romanian

Keywords

children, cerebellum, tumors, cognitive-affective syndromes, electrophysiology, treatment

Summary

Structure of dissertation: the thesis contains 194 pages of main text, 279 references, 7 attachments, 45 tables and 39 figures. The results obtained have been published in 52 scientific works.

Domain of study: physiology, neurosurgery, psychology. The aim and objectives of the study: to evidence the particularly of cognitive-affective disorders at children with cerebellar tumors in function of localization and lateralization of damage, optimization of diagnostic and therapeutic process. Methodology of the scientific research: clinico-physiologic, vegetative, neurophysiologic, statistical evaluations.

Novelty and study originality: was shown that at children with cerebellar tumors, the injured structures manifests different in cognitive-affective syndromes and psychomotor disorders; modifies different the activity of stem, subcortical and corticocerebral structures; appears the paroxysmal cerebral activity, that correlates with expression of cognitive disorders; disturbing activity of suprasegmental autonomic centers and hemomicrocirculation.

The scientific issue solved in the thesis: highlighting the clinical, neuropsychological and neurophysiologic features of cognitive-affective disorders in relation with localization, volume and lateralization of cerebellar damage at children, that allows optimization of diagnostic strategy, neurosurgical and conservative treatment.

Theoretical value: to evidence the dependence between the structure and expressivity of cognitive-affective disorders and localization, volume and lateralization of damaged the structure of cerebellum, the functional state cerebro-cererbal neuronal network and the indices of vegetative regulation; enlargement the knowledge about the interrelations of different physiological systems and mechanisms of restoring the functions in process of surgical and conservative treatment.

Practical value: to demonstrate the possibility of diagnostic cognitive-affective disorders at children with cerebellar tumors based on association of clinical, psychological, electrophysiological methods; to evidence the dynamical features of cognitive-affective disorders in postoperative period under the conservative treatment.

Implementation of scientific results: was done in Institute of Neurology and Neurosurgery, Medical Center “Neuronova-plus”, Clinical Hospital of Psychiatry.