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Specifics of cognitive-affective disorders at children with cerebellar tumors


Author: Litovcenco Anatolii
Degree:doctor habilitat of biology
Speciality: 03.00.13 - Human and animal physiology
Year:2012
Scientific consultants: Victor Lacusta
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Eva Gudumac
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: Institute of Physiology and Sanacreatology of the ASM
Scientific council: DH 07-03.00.13
Institute of Physiology and Sanacreatology of the ASM

Status

The thesis was presented on the 30 November, 2012
Approved by NCAA on the 20 December, 2012

Abstract

Adobe PDF document – 0.88 Mb / in romanian

Keywords

children, cerebellum, tumors, cognitive-affective syndromes, electrophysiology, treatment

Summary

Structure of dissertation: the thesis contains 194 pages of main text, 279 references, 7 attachments, 45 tables and 39 figures. The results obtained have been published in 52 scientific works.

Domain of study: physiology, neurosurgery, psychology. The aim and objectives of the study: to evidence the particularly of cognitive-affective disorders at children with cerebellar tumors in function of localization and lateralization of damage, optimization of diagnostic and therapeutic process. Methodology of the scientific research: clinico-physiologic, vegetative, neurophysiologic, statistical evaluations.

Novelty and study originality: was shown that at children with cerebellar tumors, the injured structures manifests different in cognitive-affective syndromes and psychomotor disorders; modifies different the activity of stem, subcortical and corticocerebral structures; appears the paroxysmal cerebral activity, that correlates with expression of cognitive disorders; disturbing activity of suprasegmental autonomic centers and hemomicrocirculation.

The scientific issue solved in the thesis: highlighting the clinical, neuropsychological and neurophysiologic features of cognitive-affective disorders in relation with localization, volume and lateralization of cerebellar damage at children, that allows optimization of diagnostic strategy, neurosurgical and conservative treatment.

Theoretical value: to evidence the dependence between the structure and expressivity of cognitive-affective disorders and localization, volume and lateralization of damaged the structure of cerebellum, the functional state cerebro-cererbal neuronal network and the indices of vegetative regulation; enlargement the knowledge about the interrelations of different physiological systems and mechanisms of restoring the functions in process of surgical and conservative treatment.

Practical value: to demonstrate the possibility of diagnostic cognitive-affective disorders at children with cerebellar tumors based on association of clinical, psychological, electrophysiological methods; to evidence the dynamical features of cognitive-affective disorders in postoperative period under the conservative treatment.

Implementation of scientific results: was done in Institute of Neurology and Neurosurgery, Medical Center “Neuronova-plus”, Clinical Hospital of Psychiatry.