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CNAA / Theses / 2012 / May /

Сourse and treatment of reactive arthritis, depending on the etiologic infectious agent

Author: Becheanu Natalia
Degree:doctor of medicine
Speciality: 14.00.06 - Cardiology and Rheumatology
Scientific adviser: Liliana Groppa
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: D 51-14.00.06
Public Medico-Sanitary Institution Moldavian Institute of Cardiology


The thesis was presented on the 25 May, 2012
Approved by NCAA on the 9 October, 2012


Adobe PDF document0.96 Mb / in romanian


reactive arthritis, clinical form, causative agent, a differentiated anti-bacterial treatment


It consists 121 pages of main text with comprises: introduction and 6 chapters, bibliography (123 sources), 5 appendices, 35 tables and 38 figures. The derived results have been presented in 15 scientific studies: 5 articles.

Domain of research: Rheumatology

The research objective of the study was to explore the possibilities of differential antibiotic treatment in patients with different clinical forms of reactive arthritis and their influence on the criteria of quality of life for these patients.

Methodology of the research: In the study frame there have been involved the fallowing research methods: history, physical examination, laboratory testing, special investigations, and statistical methods.

Scientific novelty and originality was in the comparative study of the effectiveness of doxycycline, levofloxacin and josamycin in different clinical forms of reactive arthritis. The study of the dynamical evolution of the articular syndrome, frequency and duration of remission in intestinal, urogenital, and mixed forms of reactive arthritis and the use of different antibiotics. Determination of the influence of reactive arthritis on quality of life and changes in these parameters under the influence of antibiotic therapy.

Theoretical value of the work is to identify the clinical signs of reactive arthritis, including clinical forms and applied antibacterial treatment.

Practical significance was the differential determination of antimicrobial therapy on the pathogen detected or clinically specific form, which will effectively improve the quality of life for patients.

The results have been introduced at: Department of Rheumatology, City Clinical Hospital "Holy Trinity" in the lecture courses for doctors at improvement classes at Internal Medicine №5 (rheumatology and nephrology) Department of Internal Medicine SMFU “Nicolae Testemiţanu”.