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CNAA / Theses / 2012 / May /

Correlative particularities of the motor system and intercortical connections in healthy and in pathology


Author: Hanganu Alexandru
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Year:2012
Scientific adviser: Stanislav Groppa
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.13
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 10 May, 2012
Approved by NCAA on the 5 July, 2012

Abstract

Adobe PDF document0.90 Mb / in romanian

Keywords

motor system connectivity, epilepsy, Parkinson, stroke.

Summary

Key words: motor system connectivity, epilepsy, Parkinson, stroke.

Research domain: neurology.

Aim of study: is to evaluate the correlative intercortical connections of the motor areas in health and in pathology.

Objectives are: 1. Assessment of general features of structural and functional connectivity in the region of motor areas in healthy subjects. 2. Determining the general trends of change in structural and functional connectivity in the region of motor areas in patients with idiopathic generalised epilepsy, Parkinson‟s disease and stroke. 3. Assessing the correlative relationships and general trends of change in structural and functional connectivity in the region of motor areas, in patients and in healthy subjects.

Research novelty and originality:  For the first time are presented the interrelations for functional and structural connectivity in the motor region at different levels of brain damage.  As a premier is presented the change of cortical thickness in stroke patients compared with control subjects in the insular region, with thickness decreasing for the healthy hemisphere and increased thickness for the lesioned hemisphere.

Important scientific problem that was solved: This work presents the main criterias for cerebral plasticity changes in dependance of the level of cerebral pathology.

Theoretical value: determining connectivity changes for motor regions at different levels of cerebral damage.

Applied value: knowledge of specific criteria of brain plasticity for different cerebral levels and various pathologies, with adaptation of rehabilitation and research methods. Practical implementation: adaptation of rehabilitation and research methods of brain pathologies depending on the level of damage, by correlation with general criteria for brain plasticity and cerebral adaptation.