română | русский | english

Author: Rotaru Lilia Degree: doctor of medicine Speciality:  14.00.13 - Neurology Year: 2012 Scientific adviser: Ion Moldovanu doctor habilitat, professor, Scientific consultant: Victor Lacusta doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu" Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu" Scientific council: DH 50-14.00.13-27.03.08 State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status The thesis was presented on the 23 May, 2012 Approved by NCAA on the 5 July, 2012 Abstract – 0.93 Mb / in romanian

Keywords

Summary

Key-words: chronic migraine, ventricular asymmetry, interictal deltha activity.

Field of study: neurology, neurophysiology.

Aim and objectives of the study: to ascertain the distinct clinical pattern of chronic migraine and interictal deltha activity in patients with asymmetry of lateral ventricles of different degree.

Novelty and originality of the study: The degree of ventricular asymmetry has been determined for the first time to correlate with migraine severity and slowness of brain bioelectrical activity.

The scientific problem solved in the field. The study has shown the aggravating effect of ventricular asymmetry on chronic migraine evolution by altering brain electrogenesis wich allows to optimize chronic migraine diagnosis and preventive treatment.

Theoretical significance. The study results expand and offer a deeper understanding about the role of anatomical- structural factors in migraine evolution. Asymmetry of the lateral ventricles has been determined to be a destabilizing factor for the evolution and severity of chronic migraine clinical manifestations’. Other aspects of the study were related to the implication of lateral ventricular asymmetry in brain electrogenesis at certain levels.

The practical value consisted in determining the presence of lateral ventricular asymmetry in chronic migraine patients as a potential factor of chronification and marker of disease severity. The electrophysiological dysfunction of several brain structures in patients with chronic migraine and lateral ventricular asymmetry might be the future basis for treatments by directed micro polarization of brain structures.

Implementation of scientific results: Institute of Neurology and Neurosurgery, Neurology department of Pediatric Clinical and Municipal Hospital „V. Ignatenco”, Chair of Neurology, University Clinic Neuronova-plus, and German Diagnostic Center.

Oficial Reviewers

• Stanislav Groppa
  doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
• Gheorghe Railean
  doctor habilitat, associate professor (docent), Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care

Council's Members

• Diomid Gherman, president
  doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
• Mihail Gavriliuc, secretary
  doctor
• Victor Vovc, member
  doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
• Oleg Pascal, member
  doctor habilitat, associate professor (docent), State University of Medicine and Pharmacy "Nicolae Testemitanu"
• Vitalie Lisnic , member
  doctor habilitat, associate professor (docent), State University of Medicine and Pharmacy "Nicolae Testemitanu"

 Theses