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CNAA / Theses / 2012 / May /

Chronic migraine and lateral ventricular asymmetry (clinical, neuroimaging and electrophysiological study)


Author: Rotaru Lilia
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Year:2012
Scientific adviser: Ion Moldovanu
doctor habilitat, professor,
Scientific consultant: Victor Lacusta
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.13
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 23 May, 2012
Approved by NCAA on the 5 July, 2012

Abstract

Adobe PDF document0.93 Mb / in romanian

Keywords

chronic migraine, ventricular asymmetry, interictal deltha activity.

Summary

Key-words: chronic migraine, ventricular asymmetry, interictal deltha activity.

Field of study: neurology, neurophysiology.

Aim and objectives of the study: to ascertain the distinct clinical pattern of chronic migraine and interictal deltha activity in patients with asymmetry of lateral ventricles of different degree.

Novelty and originality of the study: The degree of ventricular asymmetry has been determined for the first time to correlate with migraine severity and slowness of brain bioelectrical activity.

The scientific problem solved in the field. The study has shown the aggravating effect of ventricular asymmetry on chronic migraine evolution by altering brain electrogenesis wich allows to optimize chronic migraine diagnosis and preventive treatment.

Theoretical significance. The study results expand and offer a deeper understanding about the role of anatomical- structural factors in migraine evolution. Asymmetry of the lateral ventricles has been determined to be a destabilizing factor for the evolution and severity of chronic migraine clinical manifestations’. Other aspects of the study were related to the implication of lateral ventricular asymmetry in brain electrogenesis at certain levels.

The practical value consisted in determining the presence of lateral ventricular asymmetry in chronic migraine patients as a potential factor of chronification and marker of disease severity. The electrophysiological dysfunction of several brain structures in patients with chronic migraine and lateral ventricular asymmetry might be the future basis for treatments by directed micro polarization of brain structures.

Implementation of scientific results: Institute of Neurology and Neurosurgery, Neurology department of Pediatric Clinical and Municipal Hospital „V. Ignatenco”, Chair of Neurology, University Clinic Neuronova-plus, and German Diagnostic Center.