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Clinical and morphological peculiarities of liver hydatidosis in children


Author: Petrovici Vergil
Degree:doctor of medicine
Speciality: 14.00.15 - Pathological Anatomy
Year:2012
Scientific adviser: Ion Fuior
doctor habilitat, professor, Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care
Scientific consultant: Stanislav Babuci
doctor habilitat, associate professor (docent), State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.15
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 18 April, 2012
Approved by NCAA on the 5 July, 2012

Abstract

Adobe PDF document1.60 Mb / in romanian

Keywords

echinococcosis, liver cystic hydatidosis, pathological anatomy, children.

Summary

Thesis structure: The dissertation paper consists of 170 pages that include: introduction, six chapters, conclusions, practical recommendations, bibliography what includes 228 sources, 120 pages of basic text, 10 tables, 117 figures. The results were published in 20 scientific works including 1 monograph.

Field of research: pathological anatomy

The aim and objectives of the study. Establishing the pathological peculiarities of liver cystic hydatidosis in children and the morpho-functional changes in relation of the vital activity of the parasite, and evolutionary forms of the disease, the associated complications and recurrences.

Objectives: the study of morphological peculiarities of hydatid cyst depending on disease types and the on vital activity of larval cyst; assessment of scolecide drugs; research of changes of hepatocellular and immunocellular components in hydatid lesions; elucidation of peculiarities in hepatic parenchyma at distance of the cysts.

Scientific novelty of the work. For the first time, were established some sequence peculiarities of pathological changes of liver hydatid cyst in children with the elucidation of structural, biological and germinative components of the parasite; was confirmed the efficacy of scolecide drugs and the antagonistic relationships in coinfection, was argued etiopathogenic features of vascularization in pericystic area and of changes in hepatic parenchyma at diverse distance of the cysts. Scientific problem solved. Establishment of hepatic hydatid cyst morphogenesis in children, to define the concept of clinical-morphological evolution of hydatid cyst and hepatic parenchymal changes at distance depending on the parasite activity, to elaborate a new strategy of pathological diagnosis.

The theoretical significance. The study results contribute to define a modern concept and an original vision on hydatid biology and morphogenesis in human infection.

Applicative value of the research. Applicative value of the research is a new strategy in the methodology of pathological diagnosis in vivo of morpho-functional peculiarities in hepatic parenchyma at distance of the cysts.

Implementation of scientific results. The research results were implemented in the work of SP N Cin PS "Natalia Gheorghiu" and in the laboratory "Surgical infections in children» from the SMPhU "Nicolae Testemiţanu", in clinical diagnostic work of the department of centralized pathological anatomy and scientific polling Pathology PMSIRIMandCHC