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Author: Casian Neonila Degree: doctor of medicine Speciality:  14.00.14 - Oncology and Radiotherapy Year: 2009 Scientific adviser: Dumitru Sofroni doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology Scientific consultant: Iurie Bulat doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology Institution: Scientific council:

Status The thesis was presented on the 9 December, 2008 Approved by NCAA on the 26 February, 2009 Abstract – 0.41 Mb / in romanian Thesis CZU 618.32 – 006 – 036.3 - 08 1.36 Mb / in romanian 129 pages

Keywords

Summary

This work presents the results of researches carried out on 281 women patients with HM, consulted ambulatory and hospitalized in the Oncology Institute from the Republic of Moldova during the period of 1989 – 2005. HM’s epidemiological aspects, risk factors, clinical, biological, morphological, of monitoring and rehabilitation particularities were studied.

The HM incidence in the Republic of Moldova during the researched period of time comprised from 2,56 till 18,86 cases for 100.000 women a year and estimated for an average of 1:3224 births, with a significant tendency to increase during the last years (R²=0,63). The role of blood level monitoring of ß-HCG was evaluated in choosing the correct treatment tactic and establishing an adjusted rehabilitation program. The importance of a psychological assistance and couple’s health evaluation in the frame of a complex approach of women patients with HM was emphasized. A monitoring algorithm of women patients with HM was elaborated, depending on the morphological form of disease and depending on the dynamic of the blood level of ß-HCG. The elaborated algorithm permits the stratification of women patients that will necessitate chemotherapy treatment. As well, the proposed monitoring algorithm permits the identification of a supplementary women patients contingent for which the chemotherapy treatment could be avoided; also this monitoring algorithm makes the connection with the chemotherapeutic treatment algorithm of women patients with HM. The including the sexual partner of the women patients with HM in the rehabilitation program is obligatory in order to minimize the disease relapse risk. The proposed tactic of approach of women patients with HM gives the opportunity to plan the pregnancy one year in advance.

Oficial Reviewers

• Valentin Friptu
  doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
• Sergiu Roşca
  doctor, associate professor (docent), Public Medical Sanitary Intitution Institute of Oncology

 Theses