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 română | русский | english

Author: Bălan Greta Degree: doctor of medicine Speciality:  03.00.07 - Microbiology Year: 2009 Scientific adviser: Iurie Roşcin doctor habilitat, professor Scientific consultant: Adrian Tănase doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova Scientific council:

Status The thesis was presented on the 25 December, 2008 Approved by NCAA on the 26 February, 2009 Abstract – 0.58 Mb / in romanian Thesis CZU [616.61-022.1+616.98]-078 16.00 Mb / in romanian 131 pages

Keywords

urinary tract infections, rapid methods, nutritive medium, laboratory diagnosis

Summary

The paper represents a cycle of scientific-applicative researches on development and improvement of diagnosis methods, cultivation medium and microreagents for rapid diagnosis of the urinary tract infections.

Experimentally, in laboratory conditions, there were determined a selective acceleration factors for rapid growth and multiplication of ethiologic agents in the urinary tract infections, on the basis of which there were developed and improved the following:

• Selective nutritive medium for rapid indication of enterobacterial grups of microorganisms;
• Selective nutritive medium for rapid indication of Staphylococcus spp.;
• Selective nutritive medium for the rapid indication of bacteries P.aeruginosa;
• Selective nutritive medium for rapid indication of fungi Candida spp.;
• Microreagent for the rapid determination of microbian oxidase;
• Microreagent for the rapid determination of microbian nitrate reductase;
• Rapid methods for determination of susceptibility of microorganisms to antibiotics.

As a rezult, there was developed a scheme for rapid diagnosis of urinary tract infections, which permit the cultivation, indication and determination of susceptibility of the ethiological agents of the UTI till 24 hours (from the moment of collection and insemination of the pathological material).

There were carried out 340 specimen, from them 217 (63,8%) – positive. In 203 (93,6%) cases there was observed one isolated, but in 14 (6,4%) cases – 2 isolated. From the positive results in 164 (75,6%) cases enterobacterial microorganisms there were isolated; 38 (17,5%) cases – staphylococci; 12 (5,5%) cases – bacteria P.aeruginosa and 3 (1,4%) cases – levuriform fungus from Candida spp.

The developed methods and microreagents are rapid, economical, sensible, specific and simple in using. They are accesible in microbiological laboratories of all levels in the curative-prophylactic network of public health services.

Oficial Reviewers

• Ecaterina Emnova
  doctor habilitat, professor, Institute of Genetics, Physiology and Plant Protection of the ASM
• Radu Cojocaru
  doctor, associate professor (docent)

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