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Mycoplasma infection in children with acute bronchopulmonary affection


Author: Neamţu Liuba
Degree:doctor of medicine
Speciality: 14.00.09 - Pediatrics
Year:2016
Scientific adviser: Svetlana Şciuca
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 22 April, 2016
Approved by NCAA on the 3 June, 2016

Abstract

Adobe PDF document – 1.34 Mb / in romanian

Thesis

CZU 616.233/.24-002-053.2+616.98:579.88

Adobe PDF document 3.18 Mb / in romanian
140 pages

Keywords

respiratory infection by Mycoplasma, bronchopulmonary affection, children, specific immunoglobulins

Summary

This thesis includes introduction, four chapters, and conclusions, bibliography of 230 sources, 125 pages of basically text, 9 tables, 39 figures and 6 annexes. The results of this thesis are published in 30 scientific articles.

Domain of the study: Pediatrics, pneumology. Aim of the study: is to evaluate clinical and immunologic peculiarities of mycoplasma infection in children with bronchopulmonary affection for determination of the evolutional characteristics and optimization of management of the patients.

Objectives of the study: is to study clinical and evolutional peculiarities of mycoplasma infection in children with bronchopulmonary affection, evaluation of immunological changes in infection produced by Mycoplasma in children with bronchopulmonary diseases. Evaluation of inflammatory processes determined by cytokines, by determination of serum levels IL2, IL4 in children with bronchopulmonary affection caused by Mycoplasma spp. Optimization of therapeutic management in patients for control of mycoplasma infection of respiratory system in children. Scientific novelty and originality. Studies have identified further evidence of the impact of mycoplasma infection in children of different age groups, with the highest frequency of occurrence in young children. Features of evolution of the disease, radiological and immunological changes were present.

Important scientific problems solved in this area was the reflection of the characteristics of infectious pulmonary inflammatory process caused by Mycoplasma infection in children of different age groups, which allowed the creation of diagnostic algorithm.

Theoretical significance of this research consists in reflections of the multilateral interaction of etiopathogenetic inflammation in pneumonia caused by Mycoplasma infection.

Applicative value of the study. The research allowed revision of the range of etiologic pathogens in children with CAP, including prominently Mycoplasma spp. infection, resulting in administration of macrolide therapy in mycoplasmal affection of bronchopulmonary system. Scientific results were implemented into practice of specialists in pulmonology branch and had allowed to determine mycoplasma infection etiologically. In addition to this, results were introduced in clinical protocols.