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Author: Irena Digol Degree: doctor of medicine Speciality:  14.00.14 - Oncology and Radiotherapy Year: 2006 Scientific adviser: Mircea Sofroni doctor habilitat, professor Scientific consultant: Iraida Iacovleva doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology Institution: Scientific council:

Status The thesis was presented on the 21 December, 2005 Approved by NCAA on the 26 January, 2006 Abstract – 0.46 Mb / in romanian

Summary

The goal of this study was to reveal the risk factors for the infection with HPV oncogene types the uterine cervix in the women of reproductive age and the scientific argumentation of practical recommendation for the prophylaxis of high oncogene risk HPV infection. According to our goal and objectives the pool consisting of 355 women of reproductive age was investigated. 250 women with sexually transmitted infections were included in the group I and 105 women without sexually transmitted infections – in the group II.

We established the HPV were highly spread among women of reproductive age in the Republic of Moldova. The women having sexually transmitted infections had HPV including their oncogene types with 1,3 frequently (р<0,01). Our study has demonstrated the high frequency of HPV oncogene types in women with the pathologies of vulvae, vagina and uterine cervix (78,3%-100%). The important place in the etiology of neoplasia of uterine cervix is confirmed by its appearance in 94,6%-100% cases of the precancer pathology and cervical cancer. The reliable risk factors for infection with HPV oncogene types were established; most of them made part of the category of those controllable and partially controllable. The criteria for the individual prognosis of the complex evaluation of the probability of the infection risk with papillomavirus oncogene types were defined. Also the prophylaxis recommendations for women from the group of attention and that of high risk for infection with HPV oncogene types, which are finally claimed to reduce infection with high risk HPV and to decrease the incidence of the uterine cervix oncological pathology, were defined.

Oficial Reviewers

• Valentin Friptu
  doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
• Serghei Maximov
  doctor habilitat, profesor universitar, Institutul Oncologic N.I. Petrov din Sankt-Petersburg, Federaţia Rusă

 Theses