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Screening, prevention and treatment of hypothyroidism in pregnancy


Author: Vera Dorogoi
Degree:doctor of medicine
Speciality: 14.00.01 - Obstetrics and Gynecology
Year:2007
Scientific adviser: Ludmila Eţco
doctor habilitat, professor, Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care
Scientific consultant: Zinaida Anestiadi
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution:
Scientific council:

Status

The thesis was presented on the 5 December, 2006
Approved by NCAA on the 18 January, 2007

Abstract

Adobe PDF document – 0.25 Mb / in romanian

Thesis

CZU 618.2+616.44-008.64-08

Adobe PDF document 0.90 Mb / in romanian
115 pages

Keywords

thyroid hormones, hypothyroidism, goiter, pregnancy, Berlamin-Modular

Summary

This study was prospective and randomized. In this study were presented results of screening of 1622 pregnant women, 6,5% from which were hypothyroid, gestational goiter prevalence was 27,2%. From 95 hypothyroid pregnant women 25 had overt hypothyroidism and 70 had subclinical hypothyroidism.

Hypothyroidism was diagnosed by determination of serum TSH and free thyroxine level (FT4) at initial visit. Also, was determined thyroid autoantibodies (thyroid peroxidase) and was measured by ultrasonography thyroid volume.

All these selected women were randomized into two groups, which received different methods of treatment and one control group, consisting from euthyroid pregnant women. We monitored sequentially thyroid function during pregnancy and pregnancy outcomes in all these three groups.

Hypothyroid pregnant women from experimental group were treated by the combination of potassium iodide (KI), L-thyroxine (LT4) and product for clinical nutrition Berlamin-Modular ( Berlin Chemie).

It was developed and introduced new method of screening, monitoring and treatment of hypothyroidism in pregnancy, which greatly improve pregnancy outcomes and parameters of thyroid function in mother.

The study results help us to develop an efficient algorithm of screening, monitoring and treatment of hypothyroidism in pregnancy.