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Particuliarities of the diagnosis and treatment of thyroid carcinoma associated with autoimmune thyroiditis


Author: Sclifos Ina
Degree:doctor of medicine
Speciality: 14.00.14 - Oncology and Radiotherapy
Year:2023
Scientific adviser: Gheorghe Ţîbîrnă
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 26 October, 2022
Approved by NCAA on the 24 February, 2023

Abstract

Adobe PDF document – 1.15 Mb / in romanian
Adobe PDF document – 1.09 Mb / in english

Thesis

CZU 618.19-006.6:618.211-089.87(043.2)

Adobe PDF document 5.72 Mb / in romanian
117 pages

Keywords

thyroid carcinoma, autoimmune thyroiditis, ultrasound-guided puncture, cytological examination, surgical treatment

Summary

Thesis structure: introduction, 4 chapters, synthesis of the obtained results, general conclusions, practical recommendations, bibliography, 4 annexes, 113 pages of printed text, 40 figures, 25 tables. The results were published in 16 scientific papers.

Study domain: Oncology and radiotherapy

Study purpose: Analysis of clinical, imaging,cytological, morphological features and results of surgical treatment to optimize the diagnostic-curative management of patients with thyroid cancer associated with autoimmune thyroiditis.

The objectives of the study:
1. Study of the frequency of thyroid carcinoma associated with autoimmune thyroiditis in the Republic of Moldova (2017-2019);
2. Implementation of the method of eco-guided aspiration puncture of thyroid gland formations within IMSP IOM and assessment of its role in the diagnosis of thyroid carcinoma associated with autoimmune thyroiditis;
3. Analysis of treatment applied to patients with thyroid carcinoma associated with autoimmune thyroiditis;
4. Development of the algorithm for the diagnosis and treatment of patients with CT associated with BP.
Scientific novelty and originality: On the autochthonous clinical material in the Republic of Moldova were studied the epidemiological peculiarities, the clinical evolution, the role of the ultrasound guided puncture of the thyroid gland as well as the postoperative histopathological examination of the thyroid carcinoma associated with the autoimmune thyroiditis. The results of the surgeries performed depending on the basic background associated with thyroid cancer (autoimmune thyroiditis or healthy background) were analyzed. A diagnostic and treatment algorithm has been developed for patients with thyroid carcinoma associated with autoimmune thyroiditis.
The scientific problem solved: The research results will allow the implementation and development of new diagnostic and surgical treatment approaches in patients with thyroid carcinoma associated with autoimmune thyroiditis.
Theoretical importance: The results of the paper aim to assess the role of echo-guided puncture of the thyroid gland as a component part of the diagnosis and treatment of thyroid carcinoma associated with autoimmune thyroiditis.
The applicative value of the paper: Practical recommendations were developed in the conduct of oncologists to optimize the diagnosis and treatment of patients with CT associated with BP, with the development of the diagnosis and treatment algorithm that will make it possible to customize treatment tactics.
Implementation of scientific results: The results of the study were implemented in the daily practice of the tumor section of the head and neck region as well as in the offices of the Diagnostic Consultative Center (CCD) of IMSP IO.