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Author: Nedova Irina Degree: doctor of chemistry Speciality:  02.00.10 - Bioorganic chemistry; chemistry of natural and physiological active compounds Year: 2009 Scientific adviser: Pavel Chintea doctor habilitat, professor, Institute of Genetics, Physiology and Plant Protection of the ASM Institution: Scientific council:

Status The thesis was presented on the 6 November, 2008 Approved by NCAA on the 22 January, 2009 Abstract – 0.41 Mb / in russian – 0.39 Mb / in romanian Thesis CZU 581.19:547.918 (043.3) 1.07 Mb / in russian 124 pages

Keywords

Summary

The work is focused on the study of steroidal glycosides isolated from Hyoscyamus niger L. (black henbane) seeds. A new plant source, containing steroidal glycosides of the spirostan, furostan and pregnan series has been found. A rational method has been developed to isolate a mixture of furostan glycosides from Hyoscyamus niger L. seeds. 17 individual steroidal glycosides (hyoscyamozides) were isolated from henbane’s seeds, which differ in the structure of aglycon and oligosaccharide chain, nine of them being novel compounds, their chemical structure was elucidated by modern physico-chemical methods.

Spirostan glycosides – hyoscyamozides А, В, В1, В2, С, С1, D and D1 are derivatives of tigogenin, and hyoscyamozide В3 that of diosgenin. Hyoscyamozides - А, В1, В2, В3 and С1 turned out to be known compounds, but they were discovered in the Hyoscyamus genus for the first time. Hyoscyamozide С2 is glycoside of 5-pregn– 16 –еn –20 –оn.

Furostan glycosides – hyoscyamozides Е, Е1, F, F1, J and J1 are derivatives of (25R)-5-furostan-3,22,26-triol, and that of Е2 of (25R)-5-furosten-3,22,26-triol. Hyoscyamozides Е1 and F1 are known compounds but before they were not discovered in the Hyoscyamus genus.

Antifungal, antiprotozoan and growth stimulating activity was determined in hyoscyamozides, the degree of which depends, in the first turn, on the nature of aglycon and on the number of sugar moieties in the carbohydrate chain. Among furostan hyoscyamozides compounds which adjust growth and development of tomato, cucumber and tobacco plants were revealed.

Oficial Reviewers

• Valentin Bobeică
  doctor habilitat, professor, Moldova State University
• Ion Dragalin
  doctor, associate professor (docent)

 Theses