Attestation committee
Accreditation committee
Expert committee
Dispositions, instructions
Normative acts
Scientific councils
Scientific advisers
Doctoral students
Postdoctoral students
CNAA logo

 română | русский | english

Hydatiform mole in the Republic of Moldova: Epidemiologic, monitoring and rehabilitation aspects

Author: Casian Neonila
Degree:doctor of medicine
Speciality: 14.00.14 - Oncology and Radiotherapy
Scientific adviser: Dumitru Sofroni
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Scientific consultant: Iurie Bulat
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Scientific council:


The thesis was presented on the 9 December, 2008
Approved by NCAA on the 26 February, 2009


Adobe PDF document0.41 Mb / in romanian


CZU 618.32 – 006 – 036.3 - 08

Adobe PDF document 1.36 Mb / in romanian
129 pages


hydatiphorm mole, epidemiology, risk factor, horionic gonadotropin, monitoring, chemotherapy, rehabilitation


This work presents the results of researches carried out on 281 women patients with HM, consulted ambulatory and hospitalized in the Oncology Institute from the Republic of Moldova during the period of 1989 – 2005. HM’s epidemiological aspects, risk factors, clinical, biological, morphological, of monitoring and rehabilitation particularities were studied.

The HM incidence in the Republic of Moldova during the researched period of time comprised from 2,56 till 18,86 cases for 100.000 women a year and estimated for an average of 1:3224 births, with a significant tendency to increase during the last years (R²=0,63). The role of blood level monitoring of ß-HCG was evaluated in choosing the correct treatment tactic and establishing an adjusted rehabilitation program. The importance of a psychological assistance and couple’s health evaluation in the frame of a complex approach of women patients with HM was emphasized. A monitoring algorithm of women patients with HM was elaborated, depending on the morphological form of disease and depending on the dynamic of the blood level of ß-HCG. The elaborated algorithm permits the stratification of women patients that will necessitate chemotherapy treatment. As well, the proposed monitoring algorithm permits the identification of a supplementary women patients contingent for which the chemotherapy treatment could be avoided; also this monitoring algorithm makes the connection with the chemotherapeutic treatment algorithm of women patients with HM. The including the sexual partner of the women patients with HM in the rehabilitation program is obligatory in order to minimize the disease relapse risk. The proposed tactic of approach of women patients with HM gives the opportunity to plan the pregnancy one year in advance.