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Tehnologii de obţinere a compuşilor complecşi moleculari ai ciclodextrinelor cu unele substanţe chimioterapice

Author: Boldescu Veaceslav
Degree:doctor of chemistry
Speciality: 05.17.10 - Special products technology (with specification of products)
Scientific adviser: Gheorghe Duca
doctor habilitat, professor, Moldova State University


The thesis was presented on the 18 December, 2008
Approved by NCAA on the 26 February, 2009


Adobe PDF document1.32 Mb / in romanian


CZU 541.572.52 : 615.012.1+ 615.281

Adobe PDF document 1.77 Mb / in romanian
121 pages


drug-cyclodextrin inclusion complex, sanguinarine, amantadine, rimantadine, β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinylpyrrolidone, kneading, co-evaporation, lyophilization


The main aim of this study was to determine the most efficient technologies and optimal parameters for obtaining of the inclusion complexes of sanguinarine, amantadine and rimantadine, with cyclodextrins.

As a result of the studies performed the following binary and ternary systems were obtained and described: sanguinarine with β-cyclodextrin and hydroxypropyl-β-cyclodextrin, with and without addition of polyvynilpyrrolidone, amantadine and rimantadine with β-cyclodextrin and hydroxypropyl-β-cyclodextrin.

It has been found that the inclusion complexes are formed in the case of the case of the sanguinarine -β-cyclodextrin, sanguinarine-hydroxypropyl-β-cyclodextrin, amantadine-β- cyclodextrin, rimantadine-β-cyclodextrin.

The optimal technological parameters of the sanguinarine-β-cyclodextrin complex obtaining have been determined: pH of the reaction medium 8.0, addition of 0.1% polyvynilpyrrolidone to the reaction medium and use of lyophilization for the obtaining of the final product. It has been found that the addition of 0.1% polyvynilpyrrolidone to the reaction medium leads to the 2.4 fold increase in the yield of the process.

In vitro studies have shown that antiproliferative activity of the sanguinarine-hydroxypropyl-β-cyclodextrin complex is higher than that of the pure sanguinarine.

Four technologies for the obtaining of the amantadine and rimantadine inclusion complexes with β-cyclodextrin and hydroxypropyl-β-cyclodextrin have been studied. It has been found that: