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Repercussions of alloxan induced diabetes on some physiologic parameters under the influence of medicinal plants extracts

Author: Tatiana Chitic
Degree:doctor of biology
Speciality: 03.00.13 - Human and animal physiology
Scientific adviser: Aurelia Crivoi
doctor habilitat, professor, Moldova State University
Scientific council:


The thesis was presented on the 6 March, 2009
Approved by NCAA on the 23 April, 2009


Adobe PDF document0.55 Mb / in romanian


CZU 616.379-008.64:616.15:591.147

Adobe PDF document 1.19 Mb / in romanian
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glandes endocrines, experimental diabetes, fitoterapy, insulin, triiodothyronine, thyroxine, gonads, metabolism, diabetes mellitus


For the first time there have been carried out scientific research of the influence of medicinal plants extracts from blackberry (Ribes nigrum), flax (Linum usitatissimum), corn stigmas (Maydis stigmata) and hawthorn (Crataegus monogira) on endocrine pancreas β-cell function, functional activity of thyroid and sexual hormones, that have given a possibility to reveal stimulating of these glands at the incipient stages of experimental diabetes. There was presented the complex study of interdependency of endocrine pancreas, thyroid and sexual hormones in alloxan induced diabetes.

The paper showed that during experimental diabetes endocrine glands increase their activity, as the adapting reaction to endogen metabolic stress caused by β-cells dysfunction. Experimental groups which without medicinal plants extract administration was determined the decrease of insulin secretor cells function. Besides, there was observed the diminution on sexual hormones concentration in alloxan treated groups that allowed evidencing the interrelation of functional deregulations during diabetes.

Thus, experimental results high lighted that vegetable complex action on hormone synthesis processes.

Medicinal plants extracts manifests biosimulative effects on β-cells from Langerhans isles of endocrine pancreas, both with increase of insulin secretion and decreasing hyperglycemic level in the body.