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CNAA / Theses / 2009 / July /

Using aspects of the grapes seed oil in the complex treatment in duodenal ulcer patients

Author: Podgurschi Lilia
Degree:doctor of medicine
Speciality: 14.00.25 - Pharmacology, Clinical Pharmacology
Scientific adviser: Victor Ghicavîi
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Vlada-Tatiana Dumbrava
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council:


The thesis was presented on the 28 July, 2009
Approved by NCAA on the 1 October, 2009


Adobe PDF document0.29 Mb / in romanian


duodenal ulcer, oxidative stress, peroxydation of lipids, antioxidant protecton, malondialdehid, superoxid dismutaze, catalaze, grapes seed oil


Clinical investigation includes of the regenerative, cell-protective and antioxidative properties of the grapes seed oil assessment obtained from local raw material in 105 patients with duodenal ulcer.

In the clinical studies the association of the grapes seed oil to standard treatment (omeprazole-claritromycine-metronidazole and famotidine-amoxicillin-metronidazole) stoppted the algic and dispeptic syndroms earlier comparative with standard treatment patients have been demonstrated.

The grapes seed oil associated with the standard treatment in duodenal ulcer patients after 12,0±2 days obtained in 92% (OCMO) and 95% (FAMO) completed cicatrization the ulcer lessions comparative with control groups patients (76%) have been demonstrated.

In patients with suplimented grapes seed oil to standard treatment results in the complet Helicobacter pylori eradication in 92% (OCMO) and 85% (FAMO) causes in comparative with 80% and 71,4% causes from the control ones. Grapes seed oil, probably, amplify antihelicobacterial action of the antibacterian drugs.

In the morfological studies of gastric mucosa the more intensive deacrease of the inflammatory process in the suplimented grapes seed oil pacients to standard treatment than in those with standard ones, manifested by the diminished quantity of interepiteliale limphocytes and neutrophyles, increasing the mucocytes activity and the superficial epithelial level height has been demonstrated.

Oxidative stress in suplimented grapes seed oil patients to standard treatment more rapidly reduced by the malonic dialdehide level decrease in gastric mucosa, gastric juice and serum. At the same time, the antioxidative system activity intensification is manifested by the superoxid dismutase level increase and total antioxidative activity in mucoasa, gastric juice and serum more intensive than in the standard treatment groups patients.