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The prospect of using an extract of Juglans regia in the prevention of iodine deficiency diseases

Author: Natalia Dudnic
Degree:doctor of biology
Speciality: 03.00.13 - Human and animal physiology
Scientific adviser: Boris Melnic
doctor habilitat, professor, Moldova State University
Scientific council:


The thesis was presented on the 15 October, 2009
Approved by NCAA on the 17 December, 2009


Adobe PDF document0.58 Mb / in romanian


thyroid gland, hypothyroidism, thyroxine, triiodothyronine, tiocyanat, Juglans regia.


Direction of investigation: investigation of the effects of an extract of green walnut hull in the prevention of iodine deficiency diseases on the background of tiocyanat action

The aim: is the investigation of green walnut hull in the prevention of iodine deficiency on the background of tiocyanat action.

Objects: elaboration of experimental model of hypothyroidism of white laboratory mice with the aim of testing of an extract of walnut, analysis of blood indices, glucose and cholesterol content in the blood against the backdrop of the influence of tiocyanat, investigation of the dynamics of T3, T4, TTG contents and histological analysis of the thyroid gland.

Methodology of scientific investigation: One of the base principles of study of the endocrine system is a comprehensive study that includes: identification of functional disorders by determining the concentration of hormones in the blood line, identification the impact of the hormonal constancy on the hormonal status of a body, establishing the etiology of endocrine diseases, getting images of the endocrine glands structure in the pathologies.

Scientific novelty and originality: new experimental data of influence of the tiocyanat on the morphological status of the thyroid gland, the synthesis and secretion of thyroid hormones were obtained. The dynamic of the renal excretion of tiocyanat was established. The effect of an extract of green walnut hull on the synthesis and secretion of T4, T3, TTG, blood indices, as a histological analysis of the thyroid gland have been investigated.

Application value: The obtained results demonstrate that walnut extract has a restorative effect on the body, have been subjected to experimental hypothyroidism, and allow us to recommend its use for treatment and prevention state of iodine deficiencyof organism.

Implementation of scientific results: in the process of didactic activity and elaboration of diploma theses at the Department of Human and Animal Physiology.