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Some clinical-paraclinical peculiarities in chronic viral hepatitis according to the level of nitrates and nitrites in the body


Author: Taran Natalia
Degree:doctor of medicine
Speciality: 14.00.05 - Internal Diseases (with specification: Pulmonology, Gastroenterology, Hepatology, Nephrology, Functional Diagnostics and Endoscopy)
Year:2010
Scientific adviser: Vlada-Tatiana Dumbrava
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Nicolae Opopol
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.05
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 25 November, 2009
Approved by NCAA on the 11 February, 2010

Abstract

Adobe PDF document0.70 Mb / in romanian

Keywords

viral chronic hepatitis, nitrates and nitrites, nitric oxide, cytochrome P450, glutathione S-transpherase, citolitic, colestatic, immuno-inflammatory syndromes, the phase of viral infection, the activity of the hepatic inflammatory process

Summary

The thesis is exposed on 134 pages, has Introduction, 6 chapters, conclusions, bibliography from 225 sources, 13 annexes, 24 graphics and 17 tables. The obtained results have been published in 20 scientific works. The studied domain: chronic viral hepatitis covering the research of the NO metabolites.

The aim of the study: evaluation of some clinical-paraclinical peculiarities in HCV correlated with the level of nitrates and nitrites in the organism.

The objectives of the study: determination of the clinical peculiarities in HCV with the evaluation of the level of nitrates and nitrites in blood and urine, of microsomal enzymes according to sex, age and period of illness; examination of the following parameters in dependence on the activity of the hepatic inflammatory process and viral infection. The hepatic syndromes have been studied and correlative connections have been established between researched parameters, the activity of the hepatic inflammatory process and the phase of viral infection.

The metodology of the study: clinical, analitical, prospective study. The considered lot included comparable groups. Selecting data for clinical research was „case-control” type.

Novelty and originality of the study: The essential role of nitrates and nitrites in pathogenetical mechanism of the activity of hepatic inflammatory process and viral infection phase has been proved. It was determined a direct correlation between the level of nitrates and nitrites in blood and urine with the activity of citolitic syndrome as well as the signs of portal hypertension, along with the rate of activity of hepatic inflammatory process and viral infection.

Theoretical and aplied value of the study shows the importance of this research in the evolution of chronic viral hepatitis: NO, being one of the main mediators of inflammation. As a criterion in the prognosis of hepatic illness evolution can serve the study of nitrates and nitrites in blood and urine. The changes in microsomal enzymes highlight the lack of balance in the antioxidant system related to the function of hepatic detoxification.

Implementation of the scientific results: Results of the study were approved as valuable and then implemented in the current curative activity of the Hepatology Division of IMCP of the Clinical Republican Hospital.