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The dynamics of digestive tract bacteriocynosis formation in children (in early postnatal period) and its maintenance at sanogene level


Author: Velciu Aliona
Degree:doctor of biology
Speciality: 03.00.13 - Human and animal physiology
Year:2010
Scientific adviser: Maria Timoşco
doctor habilitat, professor, Institute of Physiology and Sanacreatology of the ASM
Scientific consultant: Valentina Ciochină
doctor, associate professor (docent), Institute of Physiology and Sanacreatology of the ASM
Institution: Institute of Physiology and Sanacreatology of the ASM
Scientific council: DH 07-03.00.13
Institute of Physiology and Sanacreatology of the ASM

Status

The thesis was presented on the 30 April, 2010
Approved by NCAA on the 5 July, 2010

Keywords

intestinal bacteriocynosis, populating, formation, reformation and maintenance, sanogene level, dismicrobism, probiotics, microorganisms association

Summary

The thesis is exposed on 93 pages: Introduction, 4 chapters, conclusions, practical recommendations, bibliography – 215 sources, 16 charts, 7 picture-cards. Scientifical publications – 18.

Purpose: the study of dynamics and characteristics of intestinal bacteriocynosis formation in children (in early postnatal period) and elaboration of methods of its maintenance at the sanogene level.

Work objectives: to study the process of intestinal bacteriocynosis formation; to study the features of the intestinal bacteriocynosis components according to the type of feeding and intestinal diarrheal disorders; to develop an express method of determining the intestinal bacteriocynosis condition and to create a technology of developing microorganisms associations with probiotic properties; to control the formation and maintenance of microflora in children in early postnatal ontogenesis.

Methodology of scientific research: controlled formation and maintenance of human’s health; intestinal bacteriocynosis formation and populating the gastrointestinal tract with some species of microorganisms; the role of some species of microorganisms in health maintenance of a macroorganism.

Scientific innovation. For the first time, a highly active sanogene microorganisms association “Bistlac” has been developed, providing controlled formation and maintenance of bacteriocynosis at the sanogene level in children (in early postnatal period).

The scientific significance lies in establishing the ways of populating the gastrointestinal tract with various species of microorganisms and in creation of a new concept according to which the formation and maintenance of the gastrointestinal tract microbiocynosis can be performed under control with associations of probiotic bacteria.

Applicative value. There have been determined the critical periods of intestinal microbiocynosis formation; and the process of controlled populating and maintenance of probiotic microflora has been developed, as well as an express method based on testing the sanogene condition of intestinal bacteriocynosis.