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CNAA / Theses / 2010 / July /

Metabolic Syndrome: Peculiarities of Etiopathogenesis


Author: Grib Livi
Degree:doctor habilitat of medicine
Speciality: 14.00.05 - Internal Diseases (with specification: Pulmonology, Gastroenterology, Hepatology, Nephrology, Functional Diagnostics and Endoscopy)
Year:2010
Scientific consultant: Valeriu Revenco
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution:
Scientific council:

Status

The thesis was presented on the 9 July, 2010
Approved by NCAA on the 6 October, 2010

Abstract

Adobe PDF document3.80 Mb / in romanian

Keywords

metabolic syndrome, arterial hypertension, insulin resistance, obesity,hyperleptinemia, dyslipidemia, hemostasis, immunity, Nebivolol, Moxonidine

Summary

Thesis structure: introduction, 4 chapters, general conclusions, recommendations, bibliography of 268 titles, 234 pages of the main text, 52 figures, 61 tables. Obtained rezults are published in 23 scientific works, including 1 monography.

Goal: Research in RF, clinical hemodynamic, metabolic, reological, immunological, and postmenopausal aspects of MS, some therapeutic implications.

Objectives of research: Appraisal of clinical hemodynamic peculiarities, RF, carbohydrate metabolism and IR, obesity, the role of leptin, lipid profile and apolipoproteins, purine metabolism, hemostasis system, immune status, the postmenopause influence and long-term treatment with Nebivolol and Moxonidine in the patients with MS.

Novelty and originality of research: The interdependence between metabolic, hemostasis system, and immune status values was evaluated overall in the MS etiopathogenesis. The role of hyperleptinemia and leptin resistance in the MS obesity was determined. The postmenopause influence on the MS components was estimated. The peculiarities of Nebivolol and Moxonidine action in arterial hypertension treatment in MS were highlighted.

Theoretical value: In MS the values of carbohydrate, lipid, leptin, purine metabolism correlate with the hemostasis system and immune status values. Not only presence of obesity but also fat deposition type matters. As hyperleptinemia and leptin resistance are directly linked with obesity degree, they may be implicated in IR patogenesis in MS.

Applied value: For appraisal of cardiometabolic risk and principal elements in MS patogenesis it is necessary to determine not only metabolic but also hemostasis system, immune status values and leptinemia. Nebivolol and Moxonidine are indicated in arterial hypertension treatment in MS because, besides good antihypertensive effect, they do not influence unfavourably on metabolic values.

Practical implementation: The result of the study was estimated as scientific work and implemented in current curative activity of the Institute of Cardiology and didactic activity of Cardiology Department, postgraduate faculty of the SMPhU “Nicolae Testemitanu”.