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CNAA / Theses / 2005 / June /

The comparative aspects of age, surgical technic and postsurgical care in myringoplasty (clinical and experimental study)

Author: Andrei Antohi
Degree:doctor of medicine
Speciality: 14.00.04 - Otorhinolaryngology
Scientific adviser: Ion Ababii
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council:


The thesis was presented on the 15 June, 2005
Approved by NCAA on the 22 September, 2005


Adobe PDF document0.39 Mb / in romanian


myringoplasty, autofascial grafting, „under lay” surgical technic, Regesan, Solcoseril gel, concomitent surgery, anatomical and functional results


The work is based on comparative study of anatomical and functional results after myringoplasty surgery, performed by „under lay” technic – the placement of autofascial graft under meato-tympanal flap – and assisted by „Regesan” and „Solcoseril gel” – drugs with regenerative properties. 137 patients were devided in three groups: 1.first group (65 patients), to which was uded „Regesan” drug; 2. second group, to which was uded „Solcoseril gel”. 3. third (control group) – to which was used ointment of erythromycine.

The comparison of anatomical and functional results was done in 1 month, 3 – 6 months and 1 – 3 years after surgery.

The best results were obtained in first group, to which was used „Regesan”.

Clinical outcomes were confirmed by histological investigations in experimental part of the work, done on nine rabbits.

Anatomical and functional results were better in children that in adults.

Conclusion: Good anatomical and functional results were obtained in all three groups of patients, but the most cases of these results were got in first group with using of „Regesan”. As a graft in miringoplasty we recomend usage of autofascial flap. As operative surgical method we recomend an „under lay” technic.