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Homeostatic disorders of macro- and microelements in patients with chronic viral hepatitis C


Author: Maev Svetlana
Degree:doctor of medicine
Speciality: 14.00.05 - Internal Diseases (with specification: Pulmonology, Gastroenterology, Hepatology, Nephrology, Functional Diagnostics and Endoscopy)
Year:2011
Scientific adviser: Vlada-Tatiana Dumbrava
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Valentin Gudumac
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council: DH 50-14.00.05-27.03.08
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 23 February, 2011
Approved by NCAA on the 31 March, 2011

Abstract

Adobe PDF document – 0.90 Mb / in romanian

Keywords

viral chronic hepatitis С, macroelements, microelements, liver antioxidants, the phase of viral infection, the activity of the hepatic inflammatory process

Summary

The thesis is exposed on 107 pages, including Introduction, 5 chapters, conclusions, bibliography from 223 sources, 5 annexes, 15 figures and 34 tables. The obtained results have been published in 8 scientific works.

The studied domain: Internal Diseases (Hepatology).

The aim of the study: The study of macroelements (K, Na, Ca, Mg, P) and microelements (Cu, Zn) homeostasis in patients with HCV, and the establishment of the relationship with the hepatic and viral activity of the inflammatory process.

The objectives of the study: Evaluation of the seric level of macroelements (K, Na, Ca, Mg, P) and microelements (Cu, Zn), hepatic antioxidants (ceruloplasmine, superoxid dismutase) and homeostatic indexes of iron (Fe, seric feritine) depending on the demographic datas; the examination of this parameters depending on the activity level of the hepatic inflammatory process, the viral infection phase and the affection period.

Novelty and originality of the study consists in distinguishing homeostazic disturbances of microelements in patients with chronic hepatitis C from the Republic of Moldova, which were characterized by a high seric level of Copper and Iron, factors with a strong prooxidant and profibrinogenic potential which may lead to disease worsening. Homeostazic disturbances of macroelements (low level of Ca and Na and high level of Mg) denote an influence of external and internal factors on the evolution of chronic hepatitis C.

Theoretical significance of this study consisted in pointing out homeostazic peculiarities of macro- and microelements in patients with chronic hepatitis C, fact that allows to elucidate and to complete some development mechanisms of hepatic lesions in patients that suffer from this disease.

Applicable value of this study consists in seric level estimation of macro and microelements in patients with chronic hepatitis C, fact that will allow to appreciate influence of unfavourable factors in the disease evolution and to establish an effective therapeutic approach.

The results have been introduced at: Hepatology Department of Republican Clinical Hospital.