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Author: Stela Сomarnitsci Degree: doctor of medicine Speciality:  14.00.09 - Pediatrics Year: 2004 Scientific adviser: Petru Stratulat (decedat) doctor habilitat, professor, Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care Institution: Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care Scientific council: DH 53-14.00.09-27.03.08 Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care

Status The thesis was presented on the 29 June, 2004 Approved by NCAA on the 14 October, 2004 Abstract – 0.83 Mb / in romanian

Keywords

Summary

In this scientific research gives complex study of acclimatization of a cardiac, cerebral and renal hemodynamics at 270 newborns from the mothers with diferite various degree of gravity of gestosis and depending on a condition intrauterine circulation. The high correlation between disorders in a fetoplacental complex of the mothers and some clinical and resistens-haemodynamics parameters at newborns in the early period of adaptation were established. The authentic items of information on features of acclimatization of cardiovascular system with long persistence of a hyperkinetic type of circulation in newborns from the mothers with serious gestosis with formation of cardiac-cerebral deficiency are received. It is shown that the level of cardiospecific enzymes in the blood of newborns has high correlation with change in echocardiografic and clinical parameters. The persistence of the complex associated infringements of a cerebral and renal hemodynamics is proved. The clinic-biochemical markers of perinatal defeats of hipoperfusion such important hemodynamics of pools are allocated such as brain and kidneys in the period of acclimatization. The conducting Doppler-patterns of cerebral blood flow and also their dynamics during early neonatal of the period are presented. The set of changes occurring in newborns kidneys from the mothers with gestosis, is considered as long hipoperfusion with downstroke of rate of a glomerular filtration, infringement of kidneys function and the rise in level of creatinine, elongation of a phase of the oliguria. The rising debit-osmolaritis of plasma is proved at the expense of the high contents of endogenic toxins received as transplacentar, as a result of an incomplete egestion. Neoton was used with the purpose of correction haemodinamics of infringements as a source of an exogenous creatine phosphate to improvement perfusion of a brain and stabilization of a conducting type of a hemodynamics.

The developed clinics-dopplerographic approach to early diagnostics of infringements of a cardiac, cerebral and renal hemodynamics at newborn will allow to estimate objectively their gravity of a condition in the early neonatal period, that will define subsequent tactics and opportunity of well-timed and adequate correction of the revealed frustration.

Oficial Reviewers

• Maria Smişnoi
  doctor habilitat, professor
• Elizaveta Uniko
  doctor habilitat în medicină, profesor universitar, AMSP, Ucraina, Kiev

Council's Members

• Ala Cojocaru, secretary
  doctor, associate professor (docent)

 Theses