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CNAA / Theses / 2011 / May /

Ремоделирование соединительнотканной стромы и эпителио-стромальные взаимоотношения в неоплазиях шейки матки


Author: Şaptefraţi Lilian
Degree:doctor habilitat of medicine
Speciality: 14.00.15 - Pathological Anatomy
Year:2011
Scientific consultants: Anatolie Cernîi
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Raica Marius
doctor în medicină, profesor universitar, UMF „Victor Babeş”, Timişoara, România
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council: DH 50-14.00.15-26.02.04
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 18 May, 2011
Approved by NCAA on the 8 July, 2011

Abstract

Adobe PDF document – 0.39 Mb / in romanian

Keywords

цервикальная интраэпителиальная неоплазия, плоскоклеточный рак шейки матки, строма, волокна внеклеточного матрикса, альфа-актин, макрофаги CD68, лимфоциты CD3, лимфоциты CD20, тучные клетки, ангиогенез, лимфангиогенез

Summary

Thesis structure: Introduction, 6 chapters, general conclusions, recommendations, bibliography of 293 titles, 221 pages of the main text, 145 figures, 19 tables. Obtained results are published in 37 scientific works, including 1 monography.

Domain of research: anatomic pathology.

Goal: to assess the consequence and evolution of: cellular populations’ modifications, components of extracellular matrix, blood vessels, lymphatic vessels and stromal changes in accordance with lesion’s severity progression in uterine cervix neoplasia.

Objectives of research: histological, histochemical, immunohistochemical and electronooptical studying of both epithelial and stromal changes in uterine cervix neoplasia, studying of blood and lymphatic vascular networks, vascular’s density and basic vessel types related to severity of uterine cervix neoplasia, evaluation of metastasizing potential through these vessels.

Novelty and originality of research: for the first time was studied the consequence of stromal modifications in all stages of a neoplasic process. The features of tumor-induced angiogenesis and lymphangiogenesis, in uterine cervix neoplasia, were elucidated.

Theoretical value: as a result of multicomponent treating of connective stroma modifications problem, was possible to give a full immunohistochemical characterization and to propose new techniques for morphological diagnosis in this disease.

Applied value: this thesis represents a novel stage for immunohistochemical techniques implementation in Republic of Moldova – techniques with crucial importance in cellular biology and oenological practice domains. Were proposed immunohistochemical methods for characterization of angiogenic phenotype in this kind of neoplasia.

Implementation of scientific results: there was recognized the high scientific value of the results obtained in this thesis, and the methods were implemented in current activity of Institute of Oncology from Republic of Moldova, in didactic activity of Hematology, Oncology and Military Therapy department, Histology, Cytology and Embryology department, and “Morphology” laboratory of SMPhU “Nicolae Testemiţanu”, as well.