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CNAA / Theses / 2011 / May /

The impact of acute alcohol intoxication on hemorrhagic shock


Author: Vişnevschi Anatolie
Degree:doctor habilitat of medicine
Speciality: 14.00.16 - Normal and Pathological Physiology
Year:2011
Scientific consultant: Vasile Lutan
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council: DH 50-14.00.16-27.03.08
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 25 May, 2011
Approved by NCAA on the 8 July, 2011

Abstract

Adobe PDF document – 0.34 Mb / in romanian

Keywords

hemorrhagic shock (HS), enzymemia, cytokines, acute alcohol intoxication, NO synthase inhibitors, generalized inflammatory syndrome, multiple organ failure, cellular injury, mean arterial pressure. Field of study- medical sciences (normal and pathological physiology

Summary

The thesis comprises 203 pages, has an introduction, 6 chapters, synthesis of obtained results, conclusions, practical recommendations, bibliography with 238 sources; it includes 17 tables and 52 figures. The results of the study are published in 33 scientific papers.

Field of study- medical sciences (normal and pathological physiology).

Aim of study:evaluation of the relationship between blood hemodynamic, biochemical changes and morphological changes in vital organs in hemorrhagic shock with acute alcohol intoxication; and improvement of pathogenetic therapy.

Objectives of study: estimation of structural injuries in myocardium, kidneys, liver and lungs, of hemodynamic indices, enzymemia and blood cytokine levels in hemorrhagic shock; in hemorrhagic shock with acute alcohol intoxication and the evaluation of hemodynamic, biochemical and morphological status after administration of pathogenetic therapy with Difetur, Dextran-70 colloid solution and the concomitant administration of the above mentioned medications.

Scientific novelty and originality: The correlative connection between hemodynamic indices, structural changes in vital organs, enzymemia and cytokine levels have been estimated for the fist time in experimental hemorrhagic shock with alcohol intoxication. The antiinflammatory effect of isothiourea derivative- Difetur has been demonstrated for the first time in hemorrhagic shock and in hemorrhagic shock with alcohol intoxication.

Theoretical significance and practical value of the thesis: A complex study of hemodynamic, biochemical and morphological changes in hemorrhagic shock with alcohol intoxication has been conducted in premiere. The results of the study fundamentally support the explanation of pathogentic mechanisms of hemorrhagic shock with alcohol intoxication. The anti-inflammatory effect of isothiourea derivative Difetur has been appreciated through the declining enzymemia, proinflammatory cytokine levels and the decrease in degree of cellular injury.

Implementation of scientific results: The results of the research are included in lectures and seminars curricula for students, residents and practicing physicians in pharmacology, clinical pharmacology, physiology, path physiology, anesthesia and intensive care.