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CNAA / Theses / 2011 / June /

The role of perinatal factors in autonomic disorders in children

Author: Gheorghe Railean
Degree:doctor habilitat of medicine
Speciality: 14.00.13 - Neurology
Scientific consultants: Ion Moldovanu
doctor habilitat, professor,
Petru Stratulat (decedat)
doctor habilitat, professor, Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care
Institution: Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care
Scientific council: DH 50-14.00.13-27.03.08
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 1 June, 2011
Approved by NCAA on the 8 July, 2011


Adobe PDF document1.80 Mb / in romanian


autonomic pathology, perinatal factors, neurophysiological methods, cognitive functions, metabolism. Area of Research: neurology, neuropediatrics and pediatrics


Structure of the thesis: introduction, 5 chapters, general conclusions and practical recommendations, bibliography consisting of 266 sources, 4 attachments, 204 pages of core text, 48 figures and 38 tables. Results of this research were published in 57 scientific papers, including 1 patent and 1 treatise.

Goal of Research: studying the role of perinatal factors in the autonomic disorders in children of different age groups correlating with cognitive-emotional features, functional status of brain structures, metabolic indicators, opioid and immune system function, highlighting the features of cardiovascular autonomic disorders, breathing, sweating and thermoregulation, analysis of clinical correlation with the degree of vegetative, organic and cerebrovascular disease, presence of chronic somatic pathology in children. Methodology. Study was prospective and retrospective.

Scientific novelty and originality. It was demonstrated that the occurrence of autonomic disorders have the highest risk obstetric trauma and chronic hypoxia, highlighted variations cerebral dysfunction (corticocerebral, brain stem, corticocerebral-brain stem) were studied simultaneously for the first time for metabolic indicators, immune function and opioid, the state of cognitive functions in children with emotional vegetative disorders at different ages and highlighted features of adaptation processes with autonomic mechanisms regulating the cardiovascular system in children depending on the nature of the noxious perinatal factors. Scientific value and clinical applicability.

The results extend and deepen the existing knowledge about the correlation of vegetative disorders in children in clinics and regulating noxious perinatal factors, perinatal factors were phased with harmful influence on autonomic functions in children which allows the differentiation of the program for diagnosis and prevention; highlighting structures vulnerable to the harmful action of cerebral hypoxia/asphyxia and perinatal trauma in children with autonomic disorders, which also allows targeted diagnostic and therapeutic process; based on investigations of neuropsychological disorders in children of different ages vegetative features highlighting emotional, cognitive disorders, sleep-wake cycle and propose recommendations for diagnosis of disorders effectively dormant and poorly presented, on the basis of the method of mapping myocardial blood dispersions, circulation features have been highlighted, immune dysfunction features have also been highlighted. Research results: were implemented in instructivemethodical and research process in ICSDOSMC, INN, USMF, “Nicolae Testemitanu”, National Center of Reproductive Health and Medical Genetics.