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CNAA / Theses / 2011 / June /

Clinical, morphological, and imagistic features of idiopathic interstitial pneumonias


Author: Munteanu Oxana
Degree:doctor of medicine
Speciality: 14.00.05 - Internal Diseases (with specification: Pulmonology, Gastroenterology, Hepatology, Nephrology, Functional Diagnostics and Endoscopy)
Year:2011
Scientific adviser: Ion Haidarlî
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.05
State University of Medicine and Pharmacy "Nicolae Testemitanu"

Status

The thesis was presented on the 1 June, 2011
Approved by NCAA on the 8 July, 2011

Abstract

Adobe PDF document0.29 Mb / in romanian

Keywords

idiopathic interstitial pneumonias, idiopathic pulmonary fibrosis, fibrosis score, “ground-glass” score, HRCT, post-inflammatory fibrosis, dyspnea, morphology

Summary

The thesis is exposed on 143 pages including: introduction, five chapters, conclusions, 46 figures, 20 tables, 230 references. The obtained results have been published in 21 scientific papers.

Field of study: Internal Medicine, Pulmonology. The aim of the study: Emphasizing the clinical, evolutional, morphological and imaging aspects of idiopathic interstitial pneumonias.

Objectives of the study:Comparative study of the clinical and evolutional variants of idiopathic interstitial pneumonias; highlighting the imaging features of idiopathic interstitial pneumonias according to the histological pattern, estimation of the applicability of the lesion visual score based on CT / HRCT image; evaluation of imaging features of idiopathic interstitial pneumonias and post-inflammatory fibrosis (due to pneumonia associated with A H1N1 influenza), assessment of severity and prognostic factors in patients with various forms of idiopathic interstitial pneumonias. Novelty and scientific originalityconsists in highlighting the clinical, functional and evolutive pecularities according to the imaging and histological patterns for improving the diagnostic of idiopathic interstitial pneumonias. For the first time in Republic of Moldova were assessed imaging scores (fibrosis and ground glass), exercise tolerance and their prognostic value in patients with idiopathic interstitial pneumonia. There was performed a comparative analysis of various scales (BORG and MRC) for quantitative evaluation of dyspnea and highlighted their correlation with functional indexes and imaging scores.

Theoretical significance: The results of the study have proved the utility of imaging scores assessment and 6-minute walk test in patients with idiopathic interstitial pneumonia in determining diagnosis, treatment regimen and prognosis.

The practical value of the work: The results of the research were used to elaborate a diagnosis algorithm for idiopathic interstitial pneumonias.

Implementation of scientific results: methodological recommendations are implemented in the therapy department of the Republican Hospital, pulmonology department No.3 of the "Chiril Draganiuc" Pulmonology and Tuberculosis Institute and in teaching and training of medical staff at the Department of Internal Medicine N.1, “Nicolae Testemitanu” Medical University.