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CNAA / Theses / 2011 / June /

Clinical, neuroimagistical and neurophysiological peculiarities of small intracerebral hemorrhages

Author: Coşciug Lilia
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Scientific adviser: Diomid Gherman
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council: DH 50-14.00.13-27.03.08
Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 15 June, 2011
Approved by NCAA on the 5 October, 2011


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small intracerebral hemorrhages, clinical features, risk factors, cerebral CT, motor evoked potentials, life quality


The thesis for the degree of doctor in medicine „Clinical, neuroimagistical and neurophysiological peculiarities of small intracerebral hemorrhages” was elaborated by Lilia Cosciug at the Chair of Neurology of the State University of Medicine and Pharmacy „Nicolae Testemitanu” of Chisinau in 2011. Thesis contains 105 pages of main text, consists of introduction, 5 chapters, conclusions, recommendations and references (251 sources), 10 annexes, 28 tables and 25 figures. The results obtained are published in 14 scientific works.

Domain of study: The thesis concerns an important aspect of neurology, physiology and neuroimagistics.

The aim of study: was the study of risk factors, clinical peculiarities, neuroimagistical features, neurophysiological peculiarities, life quality indexes in patients with small intracerebral hemorrhages (SIH), in view of the optimization of the diagnostical process. Methodology of the scientific research: The research is a clinical, analytical and prospective study. The study set included two comparable groups. The data collection for the clinical researchwas of the type „control group”.

Novelty and originality of the study there have been brought out the clinical, neurophysiological and neuroimagistical peculiarities of the small intracerebral hemorrhages; there have been systemized the risk factors, which determine and predispose towards the start of SIH; there have been elucidated the neuroimagistical and neurophysiological aspects of SIH in correlation with motor deficit; there has been show the differing diagnostic informativity based upon the indexes of evoked motor potentiales; there have been identified the correlations of clinical manifestations with the localization of SIH at different hierarchical levels of the pyramidal tract; there has been developed the hypothesis concerning the dependency of motor changes in patients with SIH upon the injury of cerebral structures with differing concentration of motor fibers and level of reactivation of cortico-spinal pathways.

Theoretical importance and practical value of the study consists in the systemization of the risk factors directly involved in the start of the SIH and also favouring these events; in bringing into evidence the prioritary localization of the SIH in the region of the internal capsule (45% cases); in showing the clinical peculiarities depending upon the cerebral structures affected; in demonstrating the sensibility of the index of pyramidal tract reactivation during the diagnostical process of the SIH; in the estimation of life quality of patients with small intracerebral hemorrhages.