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Physiological Aspects of Apidermina for treatment of wounds

Author: Iachimova Tatiana
Degree:doctor of biology
Speciality: 03.00.13 - Human and animal physiology
Scientific adviser: Ştefan Ţurcanu
doctor habilitat, professor, Agrarian State University of Moldova
Institution: Agrarian State University of Moldova
Scientific council: DH 30-03.00.13-27.03.08
Moldova State University


The thesis was presented on the 26 August, 2011
Approved by NCAA on the 5 October, 2011


Adobe PDF document0.31 Mb / in romanian


Apidermin, injury, clinical status, red blood cells, hemoglobin, hematocrit, lymphocyte, monocyte, fibroblasts, regeneration


The structure of the theses: The work presented on 140 pages of main text and includes: introduction, literature analize, material and methods, results of the study, discussion, conclusions and suggestions, bibliography, annexes. The work contains 22 tables and 19 diagrams. The obtained results are published in 9 scientific works and 2 brevet.

The domain of study: Biology.

The aim of the work. Was a complex study of morpho-physiological changes caused by mechanical trauma and the effects of the drug Apidermin to address these changes. Development of medicinal product (drug) Apedermin and study of the action of clinical indices, morphological indices of blood and regenerative wound process of the injured animals.

Research methodology. Based on fundamental data contained in the works: Kivalkinoy V. P. (1988), Mladenov S. (1988), Struckov V. I. (1991), Turcanu S. (1976, 1996) and according to classical techniques standardizated methods. Scientific innovation. First developed on the basis of apiphitoprodacts drug - Apidermin. Was studded his influence on clinical status, the dynamics of morphological indices of blood and the course of regenerative processes. Shown its therapeutic efficacy in the treatment of infected wounds.

The theoretical significance. Theoretical aspects of the work can be used for research on the use of the claimed product with other pathologies, as well as a basis for developing new drugs based on apifitoproduktov. The practical significance is to develop: the drug, which has antimicrobial, anesthetic, trophic and stimulating regenerative processes properties; recommen¬dations for the use of the drug for the treatment of wounds, the recommendations for use of the drug after surgery.

Implementation of scientific results. Developed and implemented recommen¬da¬tions for the use of the drug in veterinary clinics of the Chisinau city. The research materials used in the learning process of the department Biotechnology in Zootechno¬logy and of the of veterinary faculty State Agrarian University of Moldova.