StatusThe thesis was presented on the 22 September, 2011
Approved by NCAA on the 11 November, 2011
Abstract– 0.25 Mb / in romanian
The thesis is presented on 105 pages. It contains the introduction, 5 chapters, a conclusion, recommendations and the 264 sources of the bibliography. The results have been published in 41 scientific papers, inclusive the monography, 3 practical guide and 7 patents.
The field of study: medical microbiology, virology, immunology.
The purpose of study: Emphasiving and evaluation of activities of pacovirine for treatment and prophylaxis of viral infections, and repairing the immunodeficiency status.
The objectives of study: Identification and assessment of antiviral, immunomodulatory and interferonogene activities of pacovirine in models of infectious viral pathology and repairing the immune status.
Scientific problem: Pacovirin has been recognized as a medical preparation possessing nonspecific antiviral activity by DNA and RNA containing viruses.
The scientific novelty and originality: For the first time, it was demonstrated the antiviral, immunomodulatory and interferonogene activities of pacovirine on the models of viral diseases etiologically caused by DNA and ARN viruses (viral hepatitis B, herpes, HIV and influenza), and in patients with compromised immune systems vaccinated against a viral hepatites B and patients liquidators by Chernobyl nuclear accident.
The scientific and practical value On the basis of viral, immunological and clinical indicators, we have argued the possibility of optimization of effectiveness treatment and prophylaxis of the acute viral hepatitis B, HIV, herpes infection, and influenza and for repairing the compromised immune status.
The implementation of scientific results: Published monograph: Hepatitis B (etiology, epidemiology, diagnosis and prevention), Practical Guide “Infection with herpes simplex virus- clinical and epidemiological features, evolution, diagnosis, treatment and prevention, National Clinical Protocols 119 and 120, Instructions for administration of Pacovirine.