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The study and evaluation of the antiviral, immunomodulatory and interferonogene activity of Pacovirine


Author: Spînu Igor
Degree:doctor of medicine
Speciality: 03.00.07 - Microbiology
Year:2011
Scientific adviser: Barinski Igor
dr. hab. în medicină, profesor universitar, academician al Academiei de Ştiinţe Naturale, Federaţia Rusă, Moscova, Institutul de virusologie „D.I.Ivanovski”
Scientific consultant: Tiberiu Holban
doctor habilitat, associate professor (docent), State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: National Center of Public Health
Scientific council: DH 09-03.00.07
Institute of Microbiology and Biotechnology of the ASM

Status

The thesis was presented on the 22 September, 2011
Approved by NCAA on the 11 November, 2011

Abstract

Adobe PDF document0.25 Mb / in romanian

Keywords

Pacovirine, hepatitis B, herpes infection, HIV, influenza virus, AND and ARN containing viruses, IFN, lymphocyte subclasses T-helper/suppressor

Summary

The thesis is presented on 105 pages. It contains the introduction, 5 chapters, a conclusion, recommendations and the 264 sources of the bibliography. The results have been published in 41 scientific papers, inclusive the monography, 3 practical guide and 7 patents.

The field of study: medical microbiology, virology, immunology.

The purpose of study: Emphasiving and evaluation of activities of pacovirine for treatment and prophylaxis of viral infections, and repairing the immunodeficiency status.

The objectives of study: Identification and assessment of antiviral, immunomodulatory and interferonogene activities of pacovirine in models of infectious viral pathology and repairing the immune status.

Scientific problem: Pacovirin has been recognized as a medical preparation possessing nonspecific antiviral activity by DNA and RNA containing viruses.

The scientific novelty and originality: For the first time, it was demonstrated the antiviral, immunomodulatory and interferonogene activities of pacovirine on the models of viral diseases etiologically caused by DNA and ARN viruses (viral hepatitis B, herpes, HIV and influenza), and in patients with compromised immune systems vaccinated against a viral hepatites B and patients liquidators by Chernobyl nuclear accident.

The scientific and practical value On the basis of viral, immunological and clinical indicators, we have argued the possibility of optimization of effectiveness treatment and prophylaxis of the acute viral hepatitis B, HIV, herpes infection, and influenza and for repairing the compromised immune status.

The implementation of scientific results: Published monograph: Hepatitis B (etiology, epidemiology, diagnosis and prevention), Practical Guide “Infection with herpes simplex virus- clinical and epidemiological features, evolution, diagnosis, treatment and prevention, National Clinical Protocols 119 and 120, Instructions for administration of Pacovirine.