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Peripheral neuropathy in multiple sclerosis: clinical – electrophysiological study

Author: Odainic Olesea
Degree:doctor of medicine
Speciality: 14.00.13 - Neurology
Scientific adviser: Vitalie Lisnic
doctor habilitat, associate professor (docent), State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.13-27.03.08
State University of Medicine and Pharmacy "Nicolae Testemitanu"


The thesis was presented on the 5 October, 2011
Approved by NCAA on the 11 November, 2011


Adobe PDF document0.76 Mb / in romanian


multiple sclerosis, neuropathy, chronic inflammatory demyelinating polineuropathy, electrophysiological examination, imunosupresive treatment


Olesea Odainic’s PhD thesis in medicine „ Peripheral neuropathy in multiple sclerosis: clinical – electrophysiological study”, Chisinau, 2011 is exposed on 116 pages of typed text and it contains: introduction, 5 chapters, conclusions and practical recommendations. The thesis is illustrated with 23 tables, 29 diagrams, 12 annexes; the bibliography index quotes 186 sources. The results were published in 15 scientific works.

Domain of research: neurology

The aim of study: to elucidate the spectrum of perihperal neuropathy and demyelinating neuropathy in multiple sclerosis, to assess the clinical – electrophysiological peculiarity of neuropathy in multiple sclerosis.

Objectives of the research: to point out the presenting features of impairment of peripheral nervous system in multiple sclerosis, to perform electrophysiological examination, to particularize clinical and electrophysiological manifestation of polineuropathy in multiple sclerosis, to determinate the efficiency of immunosupressive treatment on peripheral nerves.

Methodology of research:in the study frame there have been involved the following research methods: history taking, physical examination, functional testing, special investigation, electrophysiological examination, statistical methods.

Novelty and originality of research: it has been done a scientific study of patients with multiple sclerosis and peripheral neuropathy with establishing the clinical-electrophysiological pattern.

Theoretical value: the results of the study revealed the existense of the peripheral nervous system impairment in multiple sclerosis with establishing the clinical, electrophysiological peculiarities and adequate treatment.

Applied value: the study issued the prototype of assesment for the patient with multiple sclerosis in order to establish the damage of the peripheral nervous system and aplication of the appropriate treatment.

Practical implementation: the principles which where proved by the study have been valued in the Department of Neuroemergency of Institute of Neurology and Neurosurgery.