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Diagnostic and medical-surgical management of uropathies with malformations (UM) in newborns and children aged up to three years

Author: Celac Victoria
Degree:doctor of medicine
Speciality: 14.00.35 - Infantine Surgery
Scientific adviser: Eva Gudumac
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution: State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific council: DH 50-14.00.35-26.02.04
State University of Medicine and Pharmacy "Nicolae Testemitanu"


The thesis was presented on the 26 October, 2011
Approved by NCAA on the 22 December, 2011


Adobe PDF document1.39 Mb / in romanian


uropathies with malformations, ultrasound examination, urography, cystourethrography, scintigraphy, histopathological analysis, biochemical markers


This scientifical work comprises 211 pages, including introduction, five chapters, conclusion, 149 pages of basic text, reference list (222 sources), six annexes, 17 tables and 176 figures.

Field of study: pediatric surgery.

Purpose: was to present the limits of surgery with conservative treatment of UM in newborn and children aged 0-3 years depending on the type of congenital anomaly to improve medical and surgical treatment results.

Objectives of study: assessing the clinical, laboratory and clinico-morphological aspects of urinary tract, development of diagnostic, pharmacological, surgical, prophylaxis protocol, postoperative evaluation of UM, study of efficiency of strategies used in the diagnosis and treatment compared with traditional ones.

Research methodology: clinical, laboratory methods of research and statistical processing have been applied.

The scientific novelty of the thesis is the massive role of different diagnostic, clinical, instrumental, laboratory and histopathology options in determining the subsequent surgical strategy. The histopathological analysis enabled to evaluate features of the malformations of the superior excretory system and correlations between imaging manifestations and gross anatomical structural arhitectonial characteristics and morphometry of pathological processes. The study of biochemical markers in blood serum has allowed us to determine the intensity of inflammation, degree of alteration of the cell membranes and as a result a differentiated therapeutic tactics was approached.

Scientifical and practical value of the thesis is to determine certain absolute indications and optimal time for surgical treatment of congenital anomalies of reno-urinary system in infants and children aged 0-3 years depending on the type of congenital anomalies and superimposed complications. The thesis material was published in 28 scientifical articles and implemented in practice of departments of Pediatric Urology, Surgery of New-born of National Scientific and Practical Center of Pediatric Surgery “N. Gheorghiu”, Department of Morphopathology and teaching process in the Department of Surgery, Orthopedics and Pediatric Anesthesiology of State University of Medicine and Pharmacy “N. Testemitanu”.