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CNAA / Theses / 2012 / July /

Aspects of clinical course and risk factors of arterial hypertension in children

Author: Pîrţu Lucia
Degree:doctor of medicine
Speciality: 14.00.09 - Pediatrics
Scientific adviser: Marcu Rudi
doctor, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Valeriu Revenco
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific council: DH 53-14.00.09-27.03.08
Public Medical Sanitary Intitution Scientific Research Institute of Mother and Child Health Care


The thesis was presented on the 5 July, 2012
Approved by NCAA on the 9 October, 2012


Adobe PDF document0.29 Mb / in romanian


CZU 616.12-008.331.1-053.2

Adobe PDF document 3.20 Mb / in romanian
152 pages


hypertension, children, risk factors, clinical aspects, left ventricular hypertrophy


The thesis is exposed to 118 pages, and consists of: introduction, four chapters, conclusions and recommendations, 236 bibliographical sources, 10 annexes, 36 tables and 29 figures. The results are published in 14 scientific papers.

Domain of research: pediatrics.

Purpose: Estimation of risk factors and clinical features of evolution in hypertension in children to improve the quality of care to these patients. Study objectives: Estimating the prevalence of pre- and hypertension in children in three areas of the Republic of Moldova, finding risk factors in order to determine the impact of hypertension in children, highlighting the clinical course of arterial hypertension in children, assessing the frequency of left ventricular hypertrophy and indicators that could it determine.

Novelty and originality of research. For the first time in the country there were studied the risc factors of arterial hypertension in children based on the geographical area and living environment. The investigation process included a category of children with higher blood pressure values that are admissible for age and are considered as physiological, but which have high risk for developing hypertension. There were identified the clinical features of disease, the presence of comorbidities, the determining prognostic indicators in target organ damage.

Scientific problem solved in the dissertation. It was evaluated the clinical features and evolution of hypertension in children and highlight the repercussions of risk factors in occurrence of hypertension in childhood.

The theoretical importance. It was demonstrated the importance of risk factor elucidating in children's arterial hypertension, comorbidities, assessing blood pressure variability, pulse pressure, which are indices with prognostic value in the development of left ventricular hypertrophy.

Applied value. Based on the results it will be developed a strategy to combat cardiovascular disease in children with primary health warning on the importance of measuring blood pressure values in children, selecting risk groups, initiating a strategy for promoting a healthy lifestyle in childhood.

Implementation of scientific results. The results of research have been estimated as scientifically significant and introduced in the current activity of cardiology in Scientific Research Institute Mother and the Child Health Care and educational process of Department of Pediatrics, Medical University „Nicolae Testemitanu”.