StatusThe thesis was presented on the 29 April, 2015
Approved by NCAA on the 7 July, 2015
Abstract– 0.52 Mb / in romanian
Keywords: acute destructive bacterial pneumonia, acute hematogenic osteomyelitis, acute peritonitis, cytokines, interleukins, Polyoxidonium.
Field of study: pediatric surgery.
Purpose: To improve the results of medicinal and surgical treatment and to prevent complications owing to the improvement of diagnostics and treatment methods in managing children at the age 0 -7 depending on the type of surgical infection and its clinical features.
Objectives of study: To assess the incidence, clinical and developmental specific features, biohumoral, bacteriological, histomorphological changes and immunological etiopathogenesis of acute surgical infection in children; to develop the algorithms of diagnostics and medicinal-surgical treatment of acute surgical infection and its after-treatment assessment; to study the efficacy of treatment with immunostimulants and to compare the obtained results with those of conventional treatment.
Novelty of the research: The algorithm of diagnosis and surgical treatment based on the implementation of up-to-date immunomodulants to prevent complications was developed for the first time.
The theoretical significance: The study of biochemical markers in blood serum allowed to determine the intensity of inflammation, degree of alteration of cell membranes and differentiated therapeutic tactics.
Practical value of the thesis: The algorithms for diagnosis and treatment depending on the type of infection and acute surgical complications were developed. They improved the results of medicinal and surgical treatment.
Implementation of scientific results: The results of the study were implemented into practice in the departments of Pediatric Surgery of National Scientific and Practical Center of Pediatric Surgery “Natalia Gheorghiu” and teaching process in the Department of Surgery, Orthopedics and Pediatric Anesthesiology of Nicolae Testemiţanu State University of Medicine and Pharmacy.