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CNAA / Theses / 2015 / May /

Optimization of microbial antibiotic resistance monitoring in septic-purulent infections at the medical institution level

Author: Berdeu Ion
Degree:doctor of medicine
Speciality: 14.00.30 - Epidemiology
Scientific adviser: Viorel Prisăcari
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova


The thesis was presented on the 15 May, 2015
Approved by NCAA on the 7 July, 2015


Adobe PDF document2.15 Mb / in romanian


CZU 616.9 – 036.22 – 084:616.8-089

Adobe PDF document 6.35 Mb / in romanian
151 pages


surveillance, septic-purulent infections, antimicrobial resistance, gram-positive microorganisms, gram-negative microorganisms, antibiotics


Thesis structure: The paper is exposed on 129 pages, includes 55 figures, 12 tables, 5 appendices; consists of the following structure: introduction, five chapters, conclusions and practical recommendations, summarized in Romanian, Russian, English, 264 references, the results are reflected in 12 publications.

Research field: 331.01. Epidemiology.

The purpose of the paper: Optimization of antimicrobial resistance monitoring system in septic-purulent infections at the medical institution level. The objectives of the study: Implementation of computerized program for monitoring and controlling of antimicrobial resistance at the level of multi-profile medical institution. Study the etiological structure, spectrum of resistance/susceptibility of the causative agents of septic-purulent infections depending on the microorganism species, type and group of antibiotics, ward profile is based on the computer program. Optimization the principles of acquisition and rational use of antibiotics.

The scientific innovation of the research. The etiological structure in septic-purulent infections was elucidated on the model of multi-profile hospital, the level of antimicrobial resistance of etiological agents in septic-purulent infections was determined as well. The evolutionary peculiarities in multi-annual dynamics of etiological structure and antimicrobial resistance / susceptibility were elucidated.

The scientific problem solved. A functional system for monitoring of antimicrobial resistance at the level of medical institution was developed.

Theoretical significance and applied value of work: A computerized monitoring system was implementing based on the WHONET program at the level of multi-profile medical institution, which allowed creating the database with further analysis regarding the specificity and sensitivity of the etiologic agents in septic-purulent infections and their resistance/ sensibility to antibiotics.

Implementation of results: The study results were implemented at the Institute of Emergency Medicine and the Department of Epidemiology as teaching material for university education and postgraduate doctors.