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CNAA / Theses / 2015 / July /

Diagnosis and treatment of appendiceal mucocele


Author: Vozian Marin
Degree:doctor of medicine
Speciality: 14.00.27 - Surgery
Year:2015
Scientific adviser: Gheorghe Rojnoveanu
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Scientific consultant: Igor Mişin
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 3 July, 2015
Approved by NCAA on the 7 October, 2015

Abstract

Adobe PDF document – 2.19 Mb / in romanian

Thesis

CZU 616.346.2-003.218-089

Adobe PDF document 7.37 Mb / in romanian
144 pages

Keywords

appendiceal mucocele, pseudomyxoma peritonei, peritoneal cancer index, cytoreduction score, cytoreductive surgery, hyperthermic chemotherapy, immunohistochemistry

Summary

The thesis includes introduction, 4 chapters, resolution, conclusions, recommendations, 9 tables, 69 figures, 191 bibliographic references, 116 pages of main text. The obtained results were published in 21 scientific publications.

The research domain: 321.13 – surgery. Study aim. To improve appendiceal mucocele treatment results and to increase the efficiency of prophylaxis and treatment of its complications by means of diagnostic and treatment tactics optimization.

The research objectives. To study clinical and imaging features of the appendiceal mucocele and its complications; to determine the optimal type of surgery depending on the intraoperative features, histological type and complications; to obtain the immunohistochemical phenotype of the appendiceal and ovarian mucinous lesions; to develop an experimental model of pseudomyxoma peritonei; to study the appendiceal mucocele and pseudomyxoma peritonei surgical and combined treatment results.

The novelty and the scientific originality. The evolution, morphological and immunohistochemical features and treatment options of the appendiceal mucocele and pseudomyxoma peritonei were studied. Perioperative hyperthermic intraperitoneală chemotherapy was implemented. Experimental model of pseudomyxoma peritonei was created.

The scientific solved problemresides in improvement of the appendiceal mucinous lesions and pseudomyxoma peritonei treatment results by the means of elaboration and implementation of diagnostic and treatment protocol, thus contributing to better survival results.

The theoretical significance. The imaging diagnostic features and different treatment protocols inclusion criteria were systemized. Immunohistochemical profile features of the appendiceal mucinous lesions were described. Experimental model of pseudomyxoma peritonei was created.

The applicative value of the work. Diagnostic and treatment recommendations for appendiceal mucinous lesions were elaborated depending on the histological type, as well as surgical management of pseudomyxoma peritonei

The implementation of the scientific results. The results of the present study were implemented in Institute of Emergency Medicine, as well as in the training curricula at the Department of surgery nr.1 “Nicolae Anestiadi”, PI SMPU „Nicolae Testemitanu”.