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CNAA / Theses / 2015 / July /

The study and evaluation of influenza viruses in the pandemic and interepidemic periods

Author: Eder Veronica
Degree:doctor of biology
Speciality: 03.00.07 - Microbiology
Scientific adviser: Constantin Spînu
doctor habilitat, professor


The thesis was presented on the 9 July, 2015
Approved by NCAA on the 7 October, 2015


Adobe PDF document1.13 Mb / in romanian


CZU 578.82/.83 (043.2)

Adobe PDF document 6.37 Mb / in romanian
165 pages


influenza viruses, HA, NA, genetic group, antiviral susceptibility


Eder Veronica: “The study and evaluation of influenza viruses in the pandemic and interepidemic periods”, PhD thesis in biological sciences, Chisinau, Republic of Moldova, 2015. Thesis structure: introduction, 4 chapters, conclusions and recommendations, bibliography (191 sources), 118 pages of basic text, 22 tables, 47 figures, and 10 annexes. The results have been published in 28 scientific papers. Keywords: influenza viruses, HA, NA, genetic group, antiviral susceptibility. Field of research: 163.04 - Microbiology. The purpose of study: Study and evaluation of antigenic, phenotypic and genotypic characteristics of influenza strains isolated and identified in pandemic and inter-epidemic periods in Moldova. Research objectives: The determination and evaluation of the types/subtypes of influenza viruses in the period of the study; study and evaluation of antigenic specificities of influenza viruses strains in pandemic and interepidemică periods; study and evaluation of genetic peculiarities of A and B influenza viruses strains based on HA and NA genes in the mentioned periods; sensitivity analysis evaluating phenotypic characteristics of influenza viruses strains to antiviral remedies of latest generation (oseltamivir, zanamivir) in the highlighted periods; results achieved and optimize epidemiological and virological influenza surveillance system. The scientific novelty and originality: For the first time were obtained the original results on antigenic, genotypic and phenotypic characteristics of circulating influenza viruses during pandemic and inter-epidemic periods. Scientific problem: Highlighting and evaluation of features of influenza viruses circulating in Republic of Moldova served as arguments and methodical support to continuous improvement of implemented influenza, ARI and SARI epidemiological, clinical and virological surveillance system, connected to the requirements of WHO, ECDC and CDC. The scientific and practical value: The results allowed to highlight the virological peculiarities of influenza epidemic evolution in mentioned periods significant items used in improving the national influenza, ARI and SARI surveillance adjusted to the WHO, ECDC, CDC requirements. Obtained results allowed to identify and evaluate the place of isolated strains in the phylogenetic tree globally – extremely important circumstances to argue influenza vaccine formulation. The implementation of scientific results: The results of this research are used for clinical, epidemiological and virological influenza, ARI and SARI surveillance system improving through the implementation of new standardized methods of influenza diagnostics by approving a series of documents in order to strengthen epidemiological surveillance, systematic monitoring of influenza, ARI and SARI for organizing appropriate preventive and control measures in the context of integration in regional (EuroFlu/TESSy) and global (FluNet) surveillance networks of the WHO.