StatusThe thesis was presented on the 27 October, 2015
Approved by NCAA on the 22 December, 2015
Abstract– 0.83 Mb / in romanian
ThesisCZU C.Z.U: 616.853-053.2-07-08
6.66 Mb /
Thesis structure: introduction, four chapters, general conclusions and recommendations, bibliography of 203 titles, 9 annexes, 110 pages of basic text, 34 figures, 32 tables. Results of the scientific research are published in 18 scientific articles.
Domain of the study: Neurology, pediatrics.
Aim of the study: identification of the diagnostic peculiarities and of clinical evolution of early childhood epilepsy with the aim of optimizing treatment methods.
Objectives of the study:evaluation of epidemiological data, evaluation of clinical and evolutive peculiarities of early childhood epilepsy in our country, identification of factors that may contribute to the development of the disease, assessment of paraclinical testing results aimed at revealing diagnostic peculiarities, study of biological markers (antiphospholipid antibodies, neuron specific enolase) and evaluation of their correlation with clinical manifestations of epilepsy, elaboration of predictive models of epilepsy development in children and evaluation of factors that may contribute to the development of drug resistance.
Scientific novelty and originality: a comprehensive multidirectional study of the early childhood epilepsy.
Important scientific problems solved: Elucidiation of the clinical evolution of epilepsy in correlation with some biological markers, evaluation of factors that may contribute to epilepsy development as well as of the factors contributing to drug resistance, elaboration of predictive models with a view to optimizing therapeutic management.
Theoretical significance: evaluation of the peculiarities of diagnostic employing some biological markers (neuron specific enolase, antiphospholipidic antibodies), as well as optimization of the therapeutical management by revealing a series of predictive factors that are of importance in the development of epilepsy and in the development of drug resistance.
Applicative value of the study: evaluation of the peculiarities of diagnostic employing some biological markers could prove useful in distinguishing epilepsy from other paroxysmal phenomena, as well as in prognosing psychomotor disturbances in children with epilepsia. Knowing the pattern of preconditions as well as the predictive factors for the development of epilepsy and of drug resistance contributes to the optimization of management of this disease in children of an early age.
Implementation of the scientific results:
optimization of the diagnostic process and optimization of therapeutic assistance in epilepsy within the department of neurology of IMSP IMC. Implementation of results into didactic programs of the department of pediatrics of SUMPh "Nicolae Testemiţanu" and also into the institutional guidelines of IMSP IMC.