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CNAA / Theses / 2016 / June /

Nonspecifical reactions of human organism in the respiratory disease


Author: Calenda Olga
Degree:doctor of medicine
Speciality: 14.00.26 - Phtisiopneumology
Year:2016
Scientific adviser: Valeriu Djugostran
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Scientific consultant: Serghei Ghindă
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Institution: Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"

Status

The thesis was presented on the 30 June, 2016
Approved by NCAA on the 6 October, 2016

Abstract

Adobe PDF document – 0.73 Mb / in romanian

Thesis

CZU 616-002.5:616-092/616-003.96

Adobe PDF document 4.64 Mb / in romanian
159 pages

Keywords

adaptive reactions, infiltrative pulmonary tuberculosis, limphotrop therapy, adaptogenic drugs - BioR, Extract of Eleutherococcus

Summary

The thesis consists of introduction, 4 chapters, conclusions and recommendations, bibliography of 279 titles, 13 annexes, total volume of 159 pages of basic text, 48 tables and 10 figure. The results are published in 20 scientific papers.

Field of study: Medical sciences; general medicine; 321.07 - Phthisiopneumology. Purpose of the thesis: Thei investigation of influence of the respiratory diseases (tuberculosis, bronchial asthma in exacerbations) on the structure of the common nonspecifical adaptive reactions (CNAR) and scientific argumentation of bioactivating correction in the phthisiopneunology practice. Objectives: determination of the CNAR structure in patients with infiltrative pulmonary tuberculosis and of the comparative characteristics of the different treatment regimens effect on the CNAR, study of the structural features of the CNAR in patients with resistant tuberculosis, study of the CNAR structure and immunological parameters in patients with infiltrative pulmonary tuberculosis under the influence of adaptogenic drugs and the CNAR structure in patients with bronchial asthma in severe exacerbations.

Scientific novelty and originality: it was first investigated comparative: - the structure and evolution of the CNAR in patients with infiltrative pulmonary tuberculosis under the influence of the standard TB treatment associated with complex lymphological therapy (regional lymphotropic therapy + lymphodrainage stimulation). - the influence of the adaptogenic drug BioR on the structure of the CNAR and levels of reactivity of the human organism in patients with infiltrative pulmonary tuberculosis; - structure and evolutions of the CNAR in patients with drugsensitive and drugresistant, including MDR, tuberculosis.- structure and evolution of the CNAR in patients with bronchial asthma in severe exacerbations under the influence of hormonal lymphotropic therapy. In patients with bronchial asthma in severe exacerbations and adaptive reaction "stress" the disorders of energy metabolism’s was described in lymphocyte cell’s and demonstrated their beneficial evolutions under indirect regional endolymphatic corticosteroid therapy.

Important scientific problem solved. Modification of the standard DOTS therapy by association the lymphological methods of treatment and the adaptogenic drugs leads to positive dynamics of clinical and instrumental parameters, of the CNAR structure and the levels of human organism reactivity in patients with infiltrative pulmonary tuberculosis and bronchial asthma in severe exacerbations. Theoretical significance of this research consists: the structural features of the CNAR in patients with infiltrative pulmonary tuberculosis and the comparative characteristics of the CNAR evolution under the influence of different therapeutic regimens were studed.

Modification of the standard DOTS therapy by association the lymphological methods of treatment and the adaptogenic drugs leads to positive dynamics of the CNAR structure and the levels of human organism reactivity in patients with infiltrative pulmonary tuberculosis and bronchial asthma in severe exacerbations. In patients with bronchial asthma in severe exacerbations and adaptive reaction "stress" the disorders of energy metabolism’s was described in lymphocyte cell’s and demonstrated their beneficial evolutions under indirect regional endolymphatic corticosteroid therapy.

Value of the work: administration of both the complex lymphological therapy (regional lymphotropic therapy + lymphodrainage stimulation) and bioactivating therapy (BioR and Extract of Eleutherococcus) increase the efficacy of antituberculosis treatment. Was established an advantage of endolymphatic corticoteraphy in the improving of the structure of CNAR in patients with severe bronchial asthma in severe exacerbations.

Implementation of scientific results: Laboratory Clinical Lymphology, Laboratory Immunology and Allergology, Phthisiopneumology departments, of the Institute of Phthisiopneumology „Chiril Draganiuc”