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CNAA / Theses / 2006 / June /

Pharmacological aspects of enterosorbent carbosem.


Author: Ludmila Baxan
Degree:doctor of medicine
Speciality: 14.00.25 - Pharmacology, Clinical Pharmacology
Year:2006
Scientific adviser: Victor Ghicavîi
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Valentin Gudumac
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Institution:
Scientific council:

Status

The thesis was presented on the 19 June, 2006
Approved by NCAA on the 28 September, 2006

Abstract

Adobe PDF document0.44 Mb / in romanian

Thesis

CZU 615.246.2+615.099.08+615.038

Adobe PDF document 6.68 Mb / in romanian
145 pages


Keywords

carbosem, activated charcoal, enterosorption, sorption capacity in vitro, acute toxicity, influence on homeostasis, experimental peritonitis, the complex treatment of drugs poisonings, chronic hepatitis, chronic pancreatitis, chronic enterocolitis, urticaria

Summary

There are presented the results of sorption activity investigations of the new activated charcoal from grape seed „carbosem”.

The researches have demonstrated that the new sorbent has a broad range of sorption activity.

Carbosem in stand experience in vitro has demonstrated the moderate sorption capacity for urea, high sorption capacity for glucose and bilirubin and maximum sorption activity for creatinine.

In vivo, determining acute toxicity of carbosem, it was demonstrated that because of low toxicity of the preparation it is not possible to determine the lethal dose.

In study of the influence of enterosorbent carbosem on hemoleucogram and biochemical parameters in rats’ blood was determined that the administration of carbosem for two weeks did not cause essential modifications of the studied blood parameters.

The researches on protective capacity of carbosem in poisonings have demonstrated that in poisoning with phenobarbital and caffeine the investigated preparation reduced the lethality of animals with 80%, in poisoning with diphenhydramine – with 70%, in poisoning with chlorpromazine – with 30%. All the animals who received the lethal dose of paracetamol (LD50) and carbosem have survived.

A single administration of enterosorbent carbosem in experimental peritonitis improves the clinical evolution and decreases the level of endotoxemia that is manifested by the reduction of leucocytes, molecules with medium weight, necrotic corps.

It was established that the inclusion of enterosorbent carbosem into the complex treatment of patients with chronic diseases of gastro-intestinal tract, generalized urticaria and drugs poisonings has exerted a beneficent effect in the evolution of clinical symptoms without side effects.

We can conclude that carbosem is a new sorbent, which has a high sorption capacity for a range of exogenic and endogenic substances and can be used in medical practices. Carbosem in some aspects has a superior sorption capacity in comparison with the medical charcoal. Presented research results on carbosem allows it to be recommended as an enterosorbent in complex treatment of the drugs poisoning, infectious diseases, acute surgical infections and other diseases with dysfunction of gastrointestinal tract, liver, kidneys and metabolism.