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CNAA / Theses / 2017 / May /

Peculiarities of Chemotherapy of Malignant Tumours in Ambulatory Care Settings


Author: Monul Victoria
Degree:doctor of medicine
Speciality: 14.00.14 - Oncology and Radiotherapy
Year:2017
Scientific adviser: Victor Cernat
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Scientific consultant: Iurie Bulat
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Oncology
Institution: Public Medical Sanitary Intitution Institute of Oncology

Status

The thesis was presented on the 10 May, 2017
Approved by NCAA on the 31 May, 2017

Abstract

Adobe PDF document – 1.52 Mb / in romanian

Thesis

CZU 616-006.04-08-039.57+615.277.3(043.2)

Adobe PDF document 4.01 Mb / in romanian
202 pages

Keywords

Outpatient chemotherapy, metastatic breast, lung and colorectal cancer, response to treatment, toxicity, quality of life, economic analysis

Summary

Thesis Structure: Introduction, 4 chapters, conclusions and recommendations, bibliography of 210 titles, 9 appendices, 31 figures and 43 tables, 200 pages of main text. The obtained results were published in 12 scientific publications.

Field of Research: 321.20 - Oncology and Radiotherapy.

Purpose of Research: Improvement of outpatient chemotherapy outcomes.

Objectives of Research: Comparative evaluation of the effectiveness of outpatient and inpatient chemotherapy of advanced breast, colorectal and non-small cell lung cancer. Analysis of toxicity and assessment of the quality of life of patients undergoing chemotherapy in outpatient settings. Analysis of socio-economic aspects of outpatient chemotherapy.

Novelty and Scientific Originality: This pioneering Thesis is based on a comprehensive, controlled, non-experimental, descriptive and analytical clinical study of chemotherapy in advanced cancer patients treated in inpatient versus outpatient settings. This research has demonstrated the effectiveness of ambulatory chemotherapy of patients with advanced lung, breast and colorectal cancer with acceptable toxicity profile. It has been proved that the quality of life of patients and the treatment costs are optimal for patients treated in outpatient settings.

Important Medical Problem Solved by the Research: It has been proved that inpatient chemotherapy plans can be effectively used in outpatient settings; outpatient chemotherapy has toxicity profile and clinical response indicators identical to those of inpatient chemotherapy; quality of life and efficiency indicators are higher than those of inpatient chemotherapy.

Theoretical Importance and Applied Value of the Research: This research has led to the implementation of state-of-the-art chemotherapy treatment plans in outpatient care settings of the Oncology Institute of the Republic of Moldova. This research has also resulted in the development of the Cancer Patient Guide as well as a special grid for selecting patients for outpatient chemotherapy; the purpose of both is to increase the quality of medical care through a more rigorous control of symptoms and to improve the quality of life of cancer patients.

Implementation of Research Results: Analysis of results obtained in the course of this research has led to the implementation of state-of-the-art chemotherapy treatment plans in the Outpatient Care Unit of the Oncology Institute of the Republic of Moldova.