StatusThe thesis was presented on the 15 May, 2017
Approved by NCAA on the 31 May, 2017
Abstract– 2.32 Mb / in romanian
9.43 Mb /
Study domain: Internal Medicine, hepatology.
The purpose of the study: the research of central, pulmonary, hepatic and renal hemodynamics particularities in patients with liver cirrhosis and the pharmacological treatment methods of circulatory disorders associated with liver cirrhosis.
The objectives of the study: the elucidation of central and regional hemodynamics particularities in patients with liver cirrhosis, the evaluation of the electrophysiological activity of the heart and the exercise tolerance, the determination of the role of vasodilator and vasoconstrictor substances in the development of hemodynamic changes in liver cirrhosis, the evaluation of the comparative treatment effectiveness with non-selective β-blockers and angiotensin II receptor blockers on the main hemodynamic parameters in patients with liver cirrhosis.
Scientific novelty and originality of the study has elucidated the hemodynamics particularities in patients with liver cirrhosis, the role of vasodilator and vasoconstrictor substances in the development of progressive hemodynamic changes in liver cirrhosis, the evaluation of the effectiveness of non-selective β-blockers and angiotensin II receptor blockers on central and hepatic hemodynamics disturbances in liver cirrhosis.
The fundamentally new results for science and practice obtained from the latest research have been determined creation of a new scientific direction of major importance in the domain of hemodynamic complications in liver cirrhosis and their pharmacological correction with diverse schemes of treatment.
The theoretical significance: it was demonstrated that cirrhosis leads to significant hemodynamic changes, which are progressing as cirrhosis advances. The treatment with propranolol and carvedilol improves central and hepatic hemodynamics, especially in decompensated cirrhosis, and the treatment with losartan – in compensated liver cirrhosis.
Practical value of the work: research results argues about the necessity of early detection
of the hemodynamics changes in liver cirrhosis and their correction by pharmacological methods.
The implementation of the scientific results: the results of the study have been implemented
in the department of Gastroenterology, The Internal Diseases No 1 and No 2 in CMH
“Saint Trinity”, department of Hepatology in Republic Clinical Hospital of Republic of Moldova
and Department of Internal Medicine of the State University of Medicine and Pharmacy “Nicolae