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CNAA / Theses / 2018 / June /

The effects of artificial intraanesthetic lung ventilation with permissive hypercapnia on postoperative recovery after laparoscopic cholecystectomy


Author: Rusu Victoria
Degree:doctor of medicine
Speciality: 14.00.37 - Anaesthesiology and Reanimathology
Year:2018
Scientific adviser: Adrian Belîi
doctor habilitat, associate professor (docent), Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 27 June, 2018
Approved by NCAA on the 23 November, 2018

Abstract

Adobe PDF document0.55 Mb / in romanian

Thesis

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Keywords

permissive induced hypercapnia, normocapnia, laparoscopic cholecystectomy

Summary

Rusu Victoria, ,,The effects of artificial intraanesthetic lung ventilation with permissive hypercapnia on postoperative recovery after laparoscopic cholecystectomy‘‘,PhD thesis in Medical Sciences, Chisinau, 2018. The present thesis is written on 122 pages and includes: introduction, 4 chapters, conclusions, bibliography of 224 sources, 10 annexes, 36 figures and 11 tables. The achieved results are published in 8 scientific journals, including 2 articles without co- authors. Keywords: permissive induced hypercapnia, normocapnia, laparoscopic cholecystectomy. Field of study: Anesthesiology and intensive care. Aim of the study: Identification of anesthesia effects with intraanesthetic permissive hypercapnia ventilation in post-operative period after laparoscopic cholecystectomy. Study objectives: Assessing comorbidities in patients scheduled for laparoscopic cholecystectomy, the relationship between them and postoperative recovery. Determining the accuracy of EtCO2 monitoring. Study of postoperative consequences in patients with intraoperative permissive hypercapnia. Comparative evaluation of two groups of patients maintained in unified, intravenous general anesthesia. Evaluation of cognitive functionin pre and postoperative period. Determining the effects of permissive hypercapnia induced intraoperative for postoperative period. Scientific novelty and originality: The study revealed the effects and the clinical features of permissive hypercapnia induced intra-anesthetic. It was determined the optimal value of capnia for early recovery of patients and minimizing post-anesthetic complications. The scientific problem solved in the thesis.The result of the study was based on the role of intra-anesthetic maintenance of permissive hypercapnia under mechanical ventilation conditions with physiological ventilator parameters. Theoretical significance: There was determined the role of permissive hypercapnia induced intra-anesthetic along with its influence on patients in the intensive care unit with, ALI/ ARDS. Based on the evaluation of pre-and postoperative neuro-cognitive tests, was determined the lack of impairment of neurocognitive function. The value of the work: It was determined the optimal value of capnia to minimize PONV and early post-anesthetic recovery. Implementation of scientific results:The results of the study where implemented in daily activty of the clinical work, of the MCH „Sfânta treime‖, (c. Chișinău), SUMF „Nicolae Testemițanu‖ (Implementation act Anex 10)