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CNAA / Theses / 2018 / June /

Etiological peculiarities of nosocomial septic-purulent infections in orthopedic-traumatological inpatients departments


Author: Spătaru Diana
Degree:doctor of medicine
Speciality: 14.00.30 - Epidemiology
Year:2018
Scientific adviser: Viorel Prisăcari
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
Institution: Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova

Status

The thesis was presented on the 27 June, 2018
Approved by NCAA on the 23 November, 2018

Abstract

Adobe PDF document – 0.68 Mb / in romanian

Thesis

CZU 616.94-022.369:616-001(044)

Adobe PDF document 3.18 Mb / in romanian
145 pages

Keywords

nosocomial septic-purulent infections, etiological structure, associations of cultures, microbial antibiotic resistance, resistance to disinfectants

Summary

Thesis structure: Paper is exposed on 121 pages, it includes 41 figures, 30 tables, 2 annexes; consists of the following structure: introduction, 4 chapters, conclusions and practical recommendations, summary in Romanian, Russian, English, 345 bibliographical references, the results being reflected in 12 publications.

Study domain: 331.01. Epidemiology.

Paper aim: Optimization of microbiological monitoring and rational use of antibiotics and disinfectants in the prevention and treatment of nosocomial septic-purulent infections in orthopedic-traumatological inpatient departments.

Study objectives. Study of etiological structure in septic-purulent infections (SPI) in orthopedic and traumatology inpatient departments. Determination of resistance/susceptibility spectrum of causative agents in SPI to antibiotics and disinfectants in orthopedic and traumatology inpatient departments; elaboration of measures for optimization of microbiological monitoring, elaboration of measures for effective prevention and treatment of nosocomial septic-purulent infections in orthopedic-traumatological profile inpatient departments.

Novelty and scientific originality. Etiological structure and its peculiarities were determined according to inpatient department profile, age category, mono- and associations of cultures, degree of sensitivity/resistance of causative agents to antibiotics according to microorganism species, antibiotic type and group, isolated associations in pathologic focus, as well as depending on rational acquisition and use of antibacterial preparations. A new method of testing sensitivity/resistance of circulating strains in orthopedic and traumatology inpatient departments to disinfectants with resistance spectrum determination of circulating strains in orthopedic and traumatology inpatient departments was implemented.

Solved scientific problem. Etiological structure was determined, describing etiological peculiarities of causative agents of SPNI in orthopedic-traumatological profile inpatient departments, according to age category, monocultures and associations of cultures, resistance to antibiotics and disinfectants, which present essential elements of epidemiological surveillance and control in septic-purulent nosocomial infections emerging from the stationary profile.

Paper theoretical significance and applicative value: Results of the research complement studies on causative agents in nosocomial septicpurulent infections, to antibiotics and disinfectants according to inpatient department profile. Results of the study provide additional information for optimization of circulating hospital strains, resistance of causative agents of SPI to antibiotics and disinfectants in Traumatology and Orthopedics inpatient departments.

Results Practical implementation: Research results were implemented within Public Medico-Sanitary Institution Traumatology and Orthopedic Clinical Hospital, in "Inpatient department infections" laboratory as well as at Epidemiology Department as teaching material for university and postgraduate training of doctors, and will be a component part of national guidelines for surveillance and control in nosocomial infections