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the clinic-functional and immunological conformities in diagnosis and treatment of recurrent and chronic rhinosinusitis in children”


Author: Diana Chirtoca
Degree:doctor of medicine
Speciality: 14.00.04 - Otorhinolaryngology
Year:2006
Scientific adviser: Mihail Maniuc
doctor habilitat, professor, State University of Medicine and Pharmacy "Nicolae Testemitanu"
Scientific consultant: Serghei Ghindă
doctor habilitat, professor, Public Medical Sanitary Intitution Institute of Phthisiopneumology "Chiril Draganiuc"
Institution:
Scientific council:

Status

The thesis was presented on the 15 November, 2006
Approved by NCAA on the 21 December, 2006

Abstract

Adobe PDF document0.36 Mb / in romanian

Thesis

CZU 616.216–036.12–07–08–053.2:616-097

Adobe PDF document 1.11 Mb / in romanian
137 pages


Keywords

Rhinosinusitis chronic and recurrent, acoustic rhinometry, endoscopic examination, bacteriologic examination, Nucina, mucociliar clearance

Summary

Thesis work of the doctor Chirtoca Diana on competition of a scientific degree of the doctor of medicine with a theme: “The clinic-functional and immunological conformities in diagnosis and treatment of recurrent and chronic rhinosinusitis in children”.

The present dissertation focuses upon elaboration of the vital question in contemporary otorinolaryngology – improvement of methods for diagnosis and treatment of recurrent and chronic rhinosinusitis in children.

The work is based on comparative study of clinic-functional and immunologic results after conservative treatment on 110 children with recurrent and chronic rhinosinusitis. All the patients were divided in 2 groups: 55 children from the first group received conservative treatment and sol.Dioxidini 1%, 55 children from the second one got conservative treatment and sol.Nucina 1:20.

The aim of the experimental part of the study was to determine the impact of “Nucina” solution (Juglon) in dilution 1:20 on the mucociliary frequency, and to propose this solution for the local treatment of rhinosinusitis. The ciliated ephitelium of frog palate was used as a model. The results suggested that the differences between the mucociliary frequency on frog palates with Ringer solution and those with „Nucina” 1:20 were minor and not significant. According to obtained data, we concluded that „Nucina” is safe and effective in treatment of patients with chronic rhinosinusitis.

The leading ethiologic factors of recurrent and chronic rhinosinusitis in children were revealed. Diagnostic value of acoustic rhinometry in children was determined. The main immunological values were defined for children with recurrent and chronic rhinosinusitis.

The comparison of the results was made on 5th day, on 10th day of the treatment, after 1 month and 24 month after the first examination. The best results were obtained on the second group, so in the children whom “Nucina” was administrated.