StatusThe thesis was presented on the 4 October, 2019
Approved by NCAA on the 6 December, 2019
Abstract– 15.06 Mb / in romanian
ThesisCZU 616.64 -036 (043.2)
5.99 Mb /
Erectile disfunction. Epidemiological, medical and social considerations
Thesis of doctor habilitate in medical sciences, Chisinau, 2019 Structure of the thesis: introduction, six chapters, general conclusions and recommendations, bibliography contains 339 titles, 11 annexes, 201 pages of basic text, 86 tables, 67 figures. The results are published in 59 scientific and didactic papers.
Key words: erectile dysfunction, prevalence, risk factors, early marker. Field of the research: urology and andrology, epidemiology Purpose: To study the epidemiological, medical and social aspects of erectile dysfunction in order to assess the dimensions of the problem, to identify correlations with other comorbidities, to apply it as a marker for assessing the health of men in order to make diagnosis and treatment more efficient.
Objectives: (1) to determine the prevalence of erectile dysfunction in men in the Republic of Moldova on the basis of the main known risk factors; (2) to evaluate the correlations between erectile dysfunction and some social determinants of health and to determine their role in the occurrence and evolution of erectile dysfunction; (3) to assess the correlations between erectile dysfunction and some somatic diseases or comorbid conditions associated with identifying the possibility of using erectile dysfunction as an early marker of some diseases; (4) identifying the role of urological maladies in the onset, progression and treatment of erectile dysfunction; (5) to assess diagnosis methods of erectile dysfunction, standardized questionnaires, relevant biochemical indicators; (6) identifying the role of imaging examinations in determining the causes and methods of treating erectile dysfunction; (7) to assess treatment modalities for a patient with DE with the evaluation of the efficacy of the therapeutic agents; (8)to assess the addressability of patients with erectile dysfunction and adherence to diagnostic and treatment methods; (9) to develop practical recommendations and managerial proposals on the management of erectile dysfunction.
Scientific novelty and originality is based on the fact that this is the first study in the Republic of Moldova on erectile dysfunction and the argumentation of a new scientific concept of the use of erectile dysfunction as an early marker for cardiovascular or endocrine diseases.
The applied scientific problem of major importancewas solved. The prevalence of erectile dysfunction in the Republic of Moldova and its interconnections with the main risk factors was determined. Methodologies have been developed to evaluate the patient with erectile dysfunction, which has allowed reconceptualization of the patient's diagnostic and therapeutic behavior. Erectile dysfunction is not only a consequence of psychological imbalances or a late consequence of organic maladies, it is often an important early marker of other disease without clinical significance at the time of the primary patient's addressing.
Theoretical significance and applicative value of the paper. The present research aims to complement the contemporary scientific concepts regarding the multifactorial etiology of erectile dysfunction and the possibility of using erectile accusations as an early marker of cardiovascular or endocrine diseases. An epidemiological study on erectile dysfunction was carried out, which was an important step in the assessment of the impact of non-transmissible diseases on the health of the population.
The implementation of scientific results. Research results have been used in the development of national clinical protocols on erectile dysfunction and chronic prostatitis, it constitutes a methodological support for urologists and for decision makers in public health. The results were included in the didactic activity of USMF "Nicolae Testemitanu" by being included in the Urology university curricula, and the scientific arguments allowed to start a new optional course "Andrology and Sexopathology".